Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Relationship Formation02:12

Relationship Formation

46.2K
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
46.2K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.9K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.9K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.1K
Ending Relationships01:28

Ending Relationships

194
The dissolution of intimate relationships presents complex emotional and psychological challenges, particularly when emotional bonds are strong, the relationship is long-standing, and perceived alternatives are limited. This distress often intensifies in romantic breakups, where the initiator may experience greater turmoil than the rejected partner. Contributing factors include residual attachment, guilt over causing pain, and uncertainty about how to manage the situation. The stress is further...
194
Aging01:26

Aging

713
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
713
Relationship Growth01:27

Relationship Growth

223
Interpersonal relationships progress through stages, beginning with awareness and moving toward mutuality, where emotional connections deepen. While many relationships remain at moderate levels of mutuality, deeper connections form through self-disclosure, trust, and interdependence.Self-DisclosureSelf-disclosure involves revealing personal information, starting with surface-level details and gradually progressing to more intimate content. As trust grows, individuals feel more comfortable...
223

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reduced-Dose Post-Transplant Cyclophosphamide as Graft-Versus-Host Disease Prophylaxis in Matched Donor Allogeneic Stem Cell Transplantation: A Systematic Review of Efficacy and Toxicity.

Transplantation and cellular therapy·2026
Same author

Futuristic global cell and gene therapy regulations based on a review of today's leading frameworks.

Cytotherapy·2026
Same author

Chronic graft versus host disease in upper limb: Calling upper limb rehabilitation specialists for improving outcomes in patients.

Clinical hematology international·2026
Same author

Mother's Grief.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2025
Same author

Chimeric antigen receptor T-cell therapy for high-grade B-cell lymphoma NOS.

British journal of haematology·2025
Same author

Correction: Non-cryopreserved autologous peripheral blood stem cell transplantation for multiple myeloma and lymphoma in countries with limited resources: practice considerations from the Worldwide Network for Blood and Marrow Transplantation.

Bone marrow transplantation·2025

Related Experiment Video

Updated: Feb 6, 2026

Isolation and Transplantation of Hematopoietic Stem Cells HSCs
20:38

Isolation and Transplantation of Hematopoietic Stem Cells HSCs

Published on: February 25, 2007

24.2K

Relationship between Aging and Hematopoietic Cell Transplantation.

Margaret C Cupit-Link1, Mukta Arora2, William A Wood3

  • 1Department of Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri.

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
|August 22, 2018
PubMed
Summary

Hematopoietic cell transplantation (HCT) accelerates aging in bone marrow cells. This study explores the relationship between HCT, natural aging, and clonal hematopoiesis in older adults.

Keywords:
AgingClonal hematopoiesisHematopoietic cell transplantation

More Related Videos

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
08:53

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

16.0K
Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells
06:41

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Published on: May 19, 2023

2.6K

Related Experiment Videos

Last Updated: Feb 6, 2026

Isolation and Transplantation of Hematopoietic Stem Cells HSCs
20:38

Isolation and Transplantation of Hematopoietic Stem Cells HSCs

Published on: February 25, 2007

24.2K
Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
08:53

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

16.0K
Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells
06:41

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Published on: May 19, 2023

2.6K

Area of Science:

  • Gerontology
  • Hematology
  • Oncology

Background:

  • Hematopoietic cell transplantation (HCT) is a growing treatment for elderly cancer patients.
  • HCT is known to accelerate aging in bone marrow progenitor cells.
  • Clonal hematopoiesis is prevalent in aging populations, with or without HCT.

Purpose of the Study:

  • To investigate the interplay between natural aging, clonal hematopoiesis, and HCT effects on bone marrow.
  • To explore the clinical implications of these combined factors.

Main Methods:

  • Review of existing literature on HCT, aging, and clonal hematopoiesis.
  • Analysis of the relationship between these phenomena.

Main Results:

  • Accelerated aging of bone marrow progenitor cells is a documented effect of HCT.
  • Clonal hematopoiesis occurs independently in aging individuals.
  • The combined impact of HCT and aging on clonal hematopoiesis requires further investigation.

Conclusions:

  • Understanding the relationship between HCT, aging, and clonal hematopoiesis is crucial for elderly cancer patients.
  • Further research is needed to elucidate the clinical significance of these interactions.