Related Experiment Video
Updated: Feb 6, 2026

09:55
Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
Published on: May 30, 2016
9.4K
Intrinsic and Extrinsic Factors Affecting Skin Surface pH
Current Problems in Dermatology
|August 22, 2018
Summary
Petrolatum-based emollients help maintain healthy skin acidity. This study clarifies that these products stabilize skin pH, debunking previous findings of pH increase due to measurement artifacts.
Area of Science:
- Dermatology
- Biochemistry
- Cosmetic Science
Background:
- The skin's natural slightly acidic pH, known as the
Purpose of the Study:
- To investigate the effect of petrolatum-based emollients on skin pH.
- To address discrepancies in previous studies regarding emollient impact on skin pH.
Main Methods:
- Utilized traditional skin pH measurement techniques.
- Analyzed the influence of petrolatum-based emollients and their components on stratum corneum pH.
Main Results:
- Identified that certain petrolatum-based emollients create a protective barrier, aiding in maintaining skin's natural acidity.
- Demonstrated that observed increases in skin pH in prior studies were likely artifacts of the measurement technique.
- Provided evidence that emollients stabilize, rather than negatively affect, balanced skin pH.
Conclusions:
- Petrolatum-based emollients can support the skin's natural acid mantle.
- Researchers and clinicians should consider potential measurement artifacts when evaluating emollient effects on skin pH.
More Related Videos
Related Concept Videos
Extrinsic and Intrinsic Pathways of Hemostasis
12.9K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
12.9K
Intrinsically Disordered Proteins
19.6K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.6K
Intrinsically Disordered Proteins
2.8K
2.8K
The Extrinsic Apoptotic Pathway
8.7K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
8.7K
Factors Affecting Dissolution: Particle Size and Effective Surface Area
1.7K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.7K
The Intrinsic Apoptotic Pathway
8.6K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
8.6K

