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pH in Atopic Dermatitis.

Simon G Danby, Michael J Cork

    Current Problems in Dermatology
    |August 22, 2018
    PubMed
    Summary
    This summary is machine-generated.

    Skin pH is central to atopic dermatitis (AD) pathogenesis, impacting skin barrier function and immune responses. This review explores the critical role of skin pH in AD development and offers insights into its regulation.

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    Area of Science:

    • Dermatology
    • Immunology
    • Biochemistry

    Background:

    • Atopic dermatitis (AD), or atopic eczema, is a prevalent chronic inflammatory skin condition affecting millions globally.
    • AD pathogenesis involves complex interactions between skin barrier dysfunction, immune dysregulation, and environmental factors.
    • Skin pH is a key regulator of skin barrier homeostasis and innate immunity.

    Purpose of the Study:

    • To review current evidence linking skin pH to the pathogenesis of atopic dermatitis.
    • To elucidate the role of elevated skin pH in driving altered immune responses in AD.
    • To understand the significance of skin pH in the development of AD.

    Main Methods:

    • Literature review of existing research on skin pH and atopic dermatitis.
    • Analysis of studies investigating the relationship between skin pH, skin barrier function, and immune responses.
    • Synthesis of evidence connecting environmental factors and skin pH in AD.

    Main Results:

    • Elevated skin pH is increasingly recognized as a critical factor in AD pathogenesis.
    • Skin pH influences both skin barrier integrity and immune cell function.
    • Evidence suggests that environmental factors can exacerbate AD by altering skin pH.

    Conclusions:

    • Skin pH is a central and unifying factor in atopic dermatitis pathogenesis.
    • Targeting skin pH may offer a novel therapeutic strategy for managing AD.
    • Further research is warranted to fully understand and leverage the role of skin pH in AD.