[Contrast-Induced Acute R enal Injury After Percutaneous Coronary InterventionI in Patients With ST-Segment Elevation

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Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
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Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

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E M Mezhonov1, Y A Vyalkina2, K A Vakulchik2

  • 1State Budgetary Institution of Health Care of Tyumen Region, "Regional Clinical Hospital #1".

Kardiologiia
|August 23, 2018
PubMed

Insights

Contrast-induced acute kidney injury (CI-AKI) affects nearly 30% of ST-elevation myocardial infarction (STEMI) patients post-PCI. CI-AKI significantly increases hospital and cardiovascular mortality risks.

Area of Science:

  • Cardiology
  • Nephrology
  • Interventional Cardiology

Background:

  • ST-elevation myocardial infarction (STEMI) is a critical condition requiring urgent intervention.
  • Percutaneous coronary intervention (PCI) is a standard treatment for STEMI.
  • Contrast-induced acute kidney injury (CI-AKI) is a potential complication following contrast media administration during PCI.

Purpose of the Study:

  • To determine the incidence of CI-AKI in STEMI patients undergoing PCI.
  • To evaluate the prognostic significance of CI-AKI on patient outcomes.
  • To explore the relationship between CI-AKI and glomerular filtration rate.

Main Methods:

  • Prospective observational study involving 233 STEMI patients.
  • Monitoring for CI-AKI development post-PCI over a 6-month follow-up period.
  • Statistical analysis to correlate CI-AKI with STEMI outcomes, including mortality.

Main Results:

  • CI-AKI occurred in 29.6% of the studied STEMI patients.
  • Patients with CI-AKI exhibited significantly higher hospital mortality (14.5% vs. 6.1%) and 6-month cardiovascular mortality (17.4% vs. 7.3%).
  • CI-AKI was independently associated with an increased risk of in-hospital death (OR 2.6, p=0.042) and linked to impaired glomerular filtration rate.

Conclusions:

  • CI-AKI is a frequent complication after PCI in STEMI patients.
  • The presence of CI-AKI is a significant predictor of adverse outcomes, including increased mortality.
  • Glomerular filtration rate is a relevant factor in the development of CI-AKI.
Abstract

Keywords:
ST­-elevation myocardial infarctioncontrast-­induced acute kidney injury

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