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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
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[Fibrogenesis Genes and Susceptibility to Coronary Atherosclerosis]

I A Goncharova1, T B Pecherina2, A V Markov1

  • 1Research Institute of Medical Genetics.

Kardiologiia
|August 23, 2018
PubMed

Insights

Genetic variations in fibrogenesis, lipid metabolism, immune function, and DNA repair genes influence coronary atherosclerosis susceptibility and disease progression. Specific gene polymorphisms increase or decrease the risk of developing atherosclerosis and myocardial infarction.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Biology
  • Medical Genetics

Background:

  • Coronary atherosclerosis is a complex disease influenced by genetic and environmental factors.
  • Understanding the genetic basis of atherosclerosis is crucial for developing targeted prevention and treatment strategies.

Purpose of the Study:

  • To investigate the association between specific gene polymorphisms and the risk of developing coronary atherosclerosis.
  • To identify genetic markers that predict the course and prognosis of atherosclerotic disease.

Main Methods:

  • Analysis of 48 single nucleotide polymorphisms (SNPs) in genes related to cardiovascular diseases in 404 patients with ischemic heart disease and 285 controls.
  • Genotyping performed using multiplex genotyping with mass spectrometry.
  • Statistical analysis using Statistica v8.0 and R-language.

Main Results:

  • Specific genotypes of ITGB5, ITGA4, and IGFBP7 were associated with increased susceptibility to atherosclerosis.
  • Genotypes of TLR4, LDLR, and OAS1 were found to be protective against myocardial infarction and associated with a stable disease course.
  • Identified genetic markers influencing both the development and progression of atherosclerotic disease.

Conclusions:

  • Polymorphisms in genes involved in extracellular matrix metabolism, fibrogenesis, lipid metabolism, immune function, and DNA repair are associated with coronary atherosclerosis.
  • These findings highlight the role of specific genetic variations in cardiovascular disease pathogenesis and prognosis.
  • Genetic profiling may aid in predicting individual risk and tailoring therapeutic interventions for coronary atherosclerosis.
Abstract

Keywords:
ADAMDEC1CDKN2B-AS1ITGA4ITGB5LIG1OAS1TLR4atherosclerosiscoronary artery diseasegene polymorphismmyocardial infarction

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