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Updated: Feb 6, 2026

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
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[Circulating tumour DNA: Current detection methods, use in radiotherapy and future development].

J Castelli1, L Cabel2, F-C Bidard2

  • 1Département de radiothérapie, centre Eugène-Marquis, avenue de la Bataille-Flandre-Dunkerque, 35000 Rennes, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|August 23, 2018
PubMed
Summary

Detecting circulating tumor DNA (ctDNA) in blood shows promise for cancer treatment, impacting care before, during, and after therapy. Further research into ctDNA methods and applications is crucial for clinical integration.

Keywords:
ADN tumoral circulantBiopsie liquideCirculating tumour DNALiquid biopsyMédecine personnaliséePersonalized medicinePrognosisPronosticRadiotherapyRadiothérapie

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Area of Science:

  • Oncology
  • Molecular Diagnostics
  • Radiotherapy

Background:

  • Technological advancements allow for the detection and quantification of circulating tumor DNA (ctDNA) in blood.
  • ctDNA analysis has significant potential clinical implications, especially for cancers targeted with curative intent.

Purpose of the Study:

  • To review the principles and applications of ctDNA detection and quantification.
  • To discuss the current methods for detecting ctDNA.
  • To explore the role of ctDNA in oncology, with a specific focus on radiotherapy.

Main Methods:

  • Review of current scientific literature on ctDNA detection methods.
  • Analysis of the clinical implications of ctDNA in cancer treatment paradigms.
  • Discussion of ctDNA's role in the context of radiotherapy.

Main Results:

  • ctDNA detection is a rapidly evolving field with potential applications across the cancer treatment continuum (pre-treatment, during, and post-treatment).
  • Existing limitations necessitate further development for widespread clinical adoption.
  • The integration of ctDNA into clinical practice, particularly in radiotherapy, is under active investigation.

Conclusions:

  • Circulating tumor DNA analysis holds significant promise for transforming cancer care.
  • Understanding ctDNA detection principles and applications is essential for its effective clinical use.
  • Further research is needed to overcome current limitations and fully realize the potential of ctDNA in oncology and radiotherapy.