Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.9K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.9K
Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)01:16

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

3.2K
Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...
3.2K
Actin Polymerization01:42

Actin Polymerization

8.6K
Actin polymerization occurs through the head-to-tail association of binding sites on monomeric actin or G-actin to form filamentous or F-actin. The polymerization can be divided into three phases ̶  nucleation, elongation, and steady-state phase.
The nucleation phase involves forming a stable nucleus consisting of three actin monomers to form a new actin filament. Actin-binding proteins such as formins and Arp2/3 complex help filament growth post-nucleation. The Formins form straight...
8.6K
Gene Therapy00:59

Gene Therapy

27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
Second Order systems II01:18

Second Order systems II

411
In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
411

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tabletting of single-screw hot melt extruded itraconazole: HPMC-AS amorphous solid dispersion by 3D printing and direct compression.

Drug delivery and translational research·2026
Same author

Developments & Potential of Nanotechnology for the Detection and Treatment of Pancreatic Cancer.

International journal of nanomedicine·2026
Same author

Metabolic Radiosensitization by Targeting Lactate Metabolism with Microfluidic Liposomal Nanocarriers.

ACS biomaterials science & engineering·2026
Same author

Mould-Free Microneedles in a Single Step: 3D Printing with Photopolymer Resins for Transdermal Delivery.

Pharmaceutics·2025
Same author

Development of Bioceramic Bone-Inspired Scaffolds Through Single-Step Melt-Extrusion 3D Printing for Segmental Defect Treatment.

Journal of functional biomaterials·2025
Same author

Quantum Dots: Catalysts for a New Era of Precision Medicine and Biomedical Innovation.

Journal of fluorescence·2025

Related Experiment Video

Updated: Feb 6, 2026

Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots
05:43

Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots

Published on: January 13, 2023

4.4K

Stimuli Responsive Polymeric Systems for Cancer Therapy.

Ali Alsuraifi1,2, Anthony Curtis3, Dimitrios A Lamprou4

  • 1Institute of Science and Technology in Medicine, Keele University, Keele ST5 5BG, UK. a.t.y.alsuraifi@keele.ac.uk.

Pharmaceutics
|August 23, 2018
PubMed
Summary

Smart nanoscale polymer systems are revolutionizing cancer therapy by enhancing drug delivery. These advanced materials offer targeted, stimuli-responsive drug release, improving efficacy and reducing side effects for cancer patients.

Keywords:
cancer therapyintelligent polymersmart polymerstimuli responsive

More Related Videos

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm
12:12

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Published on: May 14, 2014

11.0K
Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.6K

Related Experiment Videos

Last Updated: Feb 6, 2026

Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots
05:43

Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots

Published on: January 13, 2023

4.4K
Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm
12:12

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Published on: May 14, 2014

11.0K
Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.6K

Area of Science:

  • Polymer science and nanotechnology
  • Biomedical engineering
  • Oncology

Background:

  • Nanoscale polymer systems represent a significant advancement in drug delivery.
  • Their unique properties, including enhanced functionality, targeting capabilities, and stimuli-responsive release, have spurred extensive research in cancer therapy.
  • Traditional cancer treatments often face challenges with efficacy and side effects.

Purpose of the Study:

  • This review focuses on the application of smart polymers in cancer treatment.
  • To highlight the potential of nanotechnologies as drug carriers for improved cancer therapy.
  • To discuss the development of multifunctional smart carriers for targeted and triggered drug release.

Main Methods:

  • Review of current literature on nanoscale polymer systems in cancer therapy.
  • Analysis of smart polymer functionalities, including targeting and stimuli-responsiveness (pH, temperature).
  • Evaluation of nanocarrier performance in terms of drug efficacy and penetration.

Main Results:

  • Nanoscale polymers demonstrate unparalleled potential in cancer treatment compared to other technologies.
  • Smart polymers can be engineered for targeted delivery, increasing drug efficacy and tissue penetration.
  • Multifunctional carriers responsive to internal or external triggers (e.g., pH, temperature) are emerging as key strategies.

Conclusions:

  • Nanoscale polymer systems are pivotal in advancing cancer drug delivery.
  • Smart, stimuli-responsive nanocarriers offer a promising approach to overcome cancer with minimized patient side effects.
  • Continued research in this area is crucial for developing next-generation cancer therapies.