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Updated: Feb 6, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
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Androgen-targeted therapy in men with prostate cancer: evolving practice and future considerations
E David Crawford1, Axel Heidenreich2,3, Nathan Lawrentschuk4
1University of Colorado School of Medicine, Denver, CO, USA. David.Crawford@UCDenver.edu.
Prostate Cancer and Prostatic Diseases
|August 23, 2018
Summary
Androgen deprivation therapy (ADT) for advanced prostate cancer (PCa) has advanced significantly. Lowering testosterone (T) to <20 ng/dL improves survival, with new therapies enhancing T suppression and patient outcomes.
Area of Science:
- Oncology
- Urology
- Endocrinology
Background:
- Androgen deprivation therapy (ADT) is a cornerstone for advanced prostate cancer (PCa).
- Recent scientific breakthroughs have revolutionized ADT, including new therapies and diagnostic tools.
- Understanding testosterone (T) suppression targets and genetic mutations is crucial.
Purpose of the Study:
- To review current Androgen deprivation therapy (ADT) options for advanced prostate cancer (PCa).
- To outline best practices for managing patients undergoing ADT.
- To discuss future therapeutic directions in advanced PCa.
Main Methods:
- Review of clinical profiles of up-to-date ADT options.
- Discussion of best practices in patient management.
- Exploration of future therapeutic strategies.
Main Results:
- Modern assays define castration as serum T <15 ng/dL, lower than the historical <50 ng/dL.
- Evidence supports lowering T to <20 ng/dL for improved survival and delayed progression in advanced PCa.
- New combination therapies and T suppression monitoring enhance treatment efficacy.
Conclusions:
- Personalized ADT regimens are essential, considering initiation, duration, and monitoring of T and PSA.
- Switching therapies and intermittent vs. continuous ADT should be tailored to individual patient factors.
- Optimizing ADT strategies, including T suppression targets and combination therapies, significantly improves outcomes for advanced prostate cancer.
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