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Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
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Estrogens and prostate cancer.

Ryan W Dobbs1, Neha R Malhotra1, David T Greenwald1

  • 1Department of Urology, University of Illinois at Chicago, Chicago, IL, USA.

Prostate Cancer and Prostatic Diseases
|August 23, 2018
PubMed
Summary
This summary is machine-generated.

Estrogens play a critical role in prostate cancer (CaP) development and progression, acting through various compounds and receptors. Further research into these estrogenic influences may reveal new therapeutic targets for CaP treatment.

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Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Hormonal influences, including androgens and estrogens, are established factors in prostate cancer (CaP) development and progression.
  • While androgens have been extensively studied, estrogens also play significant roles in CaP physiology and present potential therapeutic avenues.

Purpose of the Study:

  • To critically review the existing basic science and clinical evidence regarding the interaction between estrogens and prostate cancer.
  • To highlight the under-recognized contribution of estrogens to CaP development and progression.

Main Methods:

  • Literature review of current scientific and clinical evidence.
  • Analysis of the mechanisms of estrogenic influence in CaP.

Main Results:

  • Estrogenic influences in CaP encompass a range of compounds (synthetic, endogenous, fungal, plant-derived).
  • These hormones interact with cell membrane and nuclear estrogen receptors, modulating gene expression.
  • Estrogens are implicated in CaP development, physiology, and potential therapeutic strategies.

Conclusions:

  • Estrogens are an under-recognized factor in prostate cancer development and progression.
  • Further investigation into estrogenic influences may identify environmental factors and novel therapeutic targets for CaP.