Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

62.2K
Overview
62.2K
Reversible and Irreversible Processes01:14

Reversible and Irreversible Processes

5.8K
The thermodynamic processes can be classified into reversible and irreversible processes. The processes that can be restored to their initial state are called reversible processes. It is only possible if the process is in quasi-static equilibrium, i.e., it takes place in infinitesimally small steps, and the system remains at equilibrium However, these are ideal processes and do not occur naturally. An ideal system undergoing a reversible process is always in thermodynamic equilibrium within...
5.8K
Switching of BJT01:22

Switching of BJT

866
Switching behavior in Bipolar Junction Transistors (BJTs) is a fundamental aspect utilized in various electronic circuits, particularly for digital logic applications like switches and amplifiers. In a typical switching circuit, a BJT alternates between cut-off and saturation modes, corresponding to the "off" and "on" states, respectively, thus behaving like an ideal switch.
Cut-off Mode ("Off" State): In this state, both the emitter-base and collector-base junctions are...
866
Predicting Molecular Geometry02:27

Predicting Molecular Geometry

46.0K
VSEPR Theory for Determination of Electron Pair Geometries
46.0K
Prediction Intervals01:03

Prediction Intervals

3.4K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y. 
3.4K
End Point Prediction: Gran Plot01:07

End Point Prediction: Gran Plot

1.2K
A Gran plot is used to predict the equivalence volume or endpoint of a potentiometric or acid-base titration without reaching the endpoint. Typically, titration data is collected as a function of the titrant's volume up to a point less than the equivalence volume and then transformed into a linear format. The straight line is extended to the x-axis, indicating the necessary titrant volume to achieve the equivalence point.
For potentiometric titration, the Gran plot is created by plotting...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Histidine to glutamine substitutants, a regulated process that impacts cell survival and suggests histidine shortage in cancer.

Cell death discovery·2026
Same author

Comparative transcriptomics reveals shared stress and repair-associated pathway modules in proximal tubule cells exposed to platinum chemotherapeutics.

Toxicology·2026
Same author

Cellular level lipidomics of two-dimensional cultures of adherent gut epithelial cell lines confirms a metabolic switch.

The Analyst·2026
Same author

Albumin-Anchored Composite Ratios of Blood Urea Nitrogen, C-Reactive Protein, Lactate, and Creatinine for Predicting Mortality in Chronically Ill Intensive Care Unit Patients.

Journal of clinical medicine·2026
Same author

Association of Triglyceride-to-HDL-C Ratio, Triglyceride-Glucose Index, and Inflammatory Biomarkers with Mortality in Intensive Care Unit Patients with Sepsis.

Diagnostics (Basel, Switzerland)·2026
Same author

Anxiety associated with dietary intake and gut microbiome features in a cross-sectional cohort of sub-clinically anxious young women.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Feb 6, 2026

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
07:10

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

20.8K

Predictable Irreversible Switching Between Acute and Chronic Inflammation.

Abulikemu Abudukelimu1,2, Matteo Barberis1,2, Frank A Redegeld3

  • 1Department of Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands.

Frontiers in Immunology
|August 23, 2018
PubMed
Summary
This summary is machine-generated.

This study models inflammation, revealing how antigen levels can trigger irreversible chronic inflammation. Therapies targeting chronic inflammation may need fibroblast activation for lasting effects.

Keywords:
bi-stabilitycross-reacting antigeninflammationinnate immunityirreversible transitionmodeling

More Related Videos

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

18.1K
A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction
14:05

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

Published on: December 20, 2014

32.2K

Related Experiment Videos

Last Updated: Feb 6, 2026

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
07:10

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

20.8K
A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

18.1K
A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction
14:05

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

Published on: December 20, 2014

32.2K

Area of Science:

  • Immunology
  • Computational Biology
  • Systems Biology

Background:

  • Inflammation is linked to numerous diseases.
  • Mast cells release inflammatory mediators upon antigen-antibody complex binding.
  • This can lead to fibroblast activation and endogenous antigen release, potentially cross-reactive with exogenous antigens.

Purpose of the Study:

  • To develop a predictive dynamic map of the extracellular network involved in inflammation.
  • To investigate the mechanisms underlying the transition from acute to chronic inflammation.
  • To explore potential therapeutic strategies for chronic inflammatory diseases.

Main Methods:

  • Development of a computational model simulating extracellular network dynamics.
  • In silico experiments to analyze inflammation progression under varying antigen loads.
  • Analysis of network behavior, including thresholds and feedback loops, to understand inflammatory states.

Main Results:

  • The model successfully simulated the clearance of bacterial infections via acute inflammation.
  • A critical antigen threshold ('On threshold') was identified for transitioning to strong inflammation.
  • A lower 'Off threshold' was required to resolve inflammation, indicating hysteresis and potential for chronic states.
  • The transition to a high inflammatory state was found to be ultimately irreversible, even after antigen removal.

Conclusions:

  • The developed model explains the transition from acute to chronic inflammation based on antigen load and network dynamics.
  • The irreversible nature of the high inflammation state may underlie chronic inflammatory conditions.
  • Therapies for chronic inflammation, such as anti-IgLC treatments, might require fibroblast activation for sustained efficacy.