Related Experiment Video
Updated: Feb 6, 2026

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
Published on: December 5, 2017
Is there a role for immunotherapy in HER2-positive breast cancer?
Esther Holgado1,2, Jose Perez-Garcia3,4, Maria Gion1
11Ramon y Cajal University Hospital, Ctra, Colmenar Viejo km. 9,100, 28034 Madrid, Spain.
Abstract:
Although the prognosis and prediction of therapeutic benefit for breast cancer patients overexpressing the human epidermal growth factor receptor 2 (HER2) have dramatically changed with the administration of anti-HER2-targeted therapies, HER2-positive metastatic breast cancer is still an incurable disease. Thus, new and better therapeutic options are urgently needed. Among them, are the agents stemming from the field of immunology that have been the focus of impressive scientific progress and new therapeutic opportunities seem to emerge "every day" in a variety of tumor types.
Insights
New immunotherapies offer hope for HER2-positive metastatic breast cancer, an incurable disease. Research is exploring these advancements to find better treatment options for patients.
Area of Science:
- Oncology
- Immunology
- Medical Research
Background:
- HER2-positive metastatic breast cancer remains incurable despite advances in anti-HER2 therapies.
- Targeted therapies have improved outcomes but have not eradicated the disease.
Purpose of the Study:
- To highlight the urgent need for novel therapeutic strategies in HER2-positive metastatic breast cancer.
- To explore the potential of immunotherapeutic agents as a new treatment avenue.
Main Methods:
- Review of current scientific literature on HER2-positive breast cancer treatments.
- Analysis of recent progress in cancer immunology and immunotherapy development.
Main Results:
- Immunotherapy represents a rapidly advancing field with significant potential in oncology.
- Emerging immunotherapeutic agents show promise across various tumor types.
Conclusions:
- Immunotherapy holds significant promise for developing next-generation treatments for HER2-positive metastatic breast cancer.
- Continued research into immunological approaches is crucial for addressing unmet needs in breast cancer therapy.
Related Concept Videos
Tumor Immunotherapy
Position-effect Variegation
Chromatin Position Affects Gene Expression
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
Position and Displacement
Serial Position Effect
Position Vectors
For instance, we want to locate a point P(x, y, z) relative to the origin of coordinates O. In that case, we can define a position...

