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Related Concept Videos

ATP Driven Pumps III: V-type Pumps01:30

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V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma membranes of a few specialized eukaryotic cells, and some prokaryotes. They are also known as the V1Vo-ATPase, that couple ATP hydrolysis to transport protons against a concentration gradient.
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ATP Driven Pumps II: P-type Pumps01:34

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The P-type pumps are a large family of integral membrane transporter ATPases. They are divided into five major types based on substrate specificity, from I to V.
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...
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Long-patch Base Excision Repair01:02

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Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
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Concrete in large quantities can be pumped across long distances for placing in inaccessible sites. This system comprises a hopper that receives concrete from a mixer, a pump to propel the concrete, and pipelines that facilitate its delivery.
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Refrigerators and Heat Pumps01:07

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Refrigerators or heat pumps are heat engines operating in a reverse direction. For a refrigerator, the focus is on removing heat from a specific area, whereas, for a heat pump, the focus is on dumping heat into one particular area. A refrigerator (or heat pump) absorbs heat Qc from the cold reservoir at Kelvin temperature Tc and discards heat Qh to the hot reservoir at Kelvin temperature Th, while work W is done on the engine’s working substance.
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Patch Clamp01:18

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Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
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Patch Pumps: Are They All the Same?

Lutz Heinemann1, Delia Waldenmaier2, Bernd Kulzer3

  • 11 Science Consulting in Diabetes GmbH, Neuss, Germany.

Journal of Diabetes Science and Technology
|August 23, 2018
PubMed
Summary

Patch pumps offer a discreet, user-friendly, and cost-effective alternative to traditional insulin pumps for diabetes management. This review explores their technology, clinical needs, patient preferences, and future potential in artificial pancreas systems.

Keywords:
infusion setsinsulin pumpsinsulin therapypatch pumps

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Area of Science:

  • Endocrinology
  • Medical Devices
  • Diabetes Technology

Background:

  • Insulin pump therapy is increasingly adopted by diabetic patients.
  • Conventional insulin pumps have drawbacks, such as the insulin infusion set.
  • Patch pumps offer potential advantages like smaller size, discretion, ease of use, and lower cost.

Purpose of the Study:

  • To provide a comprehensive overview of insulin patch pumps.
  • To discuss the technologies, clinical requirements, and development challenges of patch pumps.
  • To explore future directions, including artificial pancreas systems.

Main Methods:

  • Literature review of insulin patch pump technology and clinical data.
  • Analysis of factors contributing to the failure of certain patch pump developments.
  • Examination of patient preferences and cost-effectiveness.

Main Results:

  • Patch pumps present several advantages over conventional insulin pumps.
  • Specific clinical studies are required to validate their efficacy and safety.
  • Patient preferences may vary across different demographic groups.

Conclusions:

  • Insulin patch pumps represent a promising advancement in diabetes care.
  • Further research and clinical evidence are necessary for widespread adoption.
  • Future developments may integrate patch pumps into artificial pancreas systems.