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Related Experiment Video

Updated: Feb 1, 2026

Induction of Endothelial Differentiation in Cardiac Progenitor Cells Under Low Serum Conditions

Induction of Endothelial Differentiation in Cardiac Progenitor Cells Under Low Serum Conditions

Published on: January 7, 2019

Revascularization and endothelial progenitor cells in stroke.

Gema Esquiva¹, Alba Grayston¹, Anna Rosell¹

¹Neurovascular Research Laboratory and Neurology Department, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona , Barcelona , Spain.

American Journal of Physiology. Cell Physiology

|August 23, 2018

Summary

Endothelial progenitor cells (EPCs) aid brain recovery after stroke by promoting new blood vessel growth and repair. This review explores how EPCs

Keywords:

angiogenesis endothelial progenitor cells neurogenesis secretome stroke

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Last Updated: Feb 1, 2026

Induction of Endothelial Differentiation in Cardiac Progenitor Cells Under Low Serum Conditions

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Published on: January 7, 2019

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

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Published on: September 14, 2017

Isolation and Large Scale Expansion of Adult Human Endothelial Colony Forming Progenitor Cells

Isolation and Large Scale Expansion of Adult Human Endothelial Colony Forming Progenitor Cells

Published on: October 27, 2009

Area of Science:

Neuroscience
Regenerative Medicine
Vascular Biology

Background:

Stroke remains a leading cause of death and disability globally.
Advances in acute stroke care have improved survival but neurological deficits persist.
Neurorehabilitation is the primary therapy for post-stroke recovery, necessitating new treatment strategies.

Purpose of the Study:

To review the neuroreparative functions of endothelial progenitor cells (EPCs) in stroke recovery.
To elucidate the paracrine signaling mechanisms employed by EPCs.
To highlight the role of EPC secretome and extracellular vesicles in neurorepair.

Main Methods:

Review of preclinical and clinical studies on EPCs in stroke models.
Analysis of EPC mobilization, differentiation, and function post-ischemia.
Investigation of paracrine factors and extracellular vesicles secreted by EPCs.

Main Results:

EPCs are crucial for angiogenesis and vascular remodeling in the ischemic brain.
Circulating EPC levels are altered following stroke.
EPC-derived secretome and extracellular vesicles mediate neuroprotective and pro-regenerative effects.

Conclusions:

EPCs hold significant therapeutic potential for stroke neurorepair.
Targeting EPC paracrine signaling offers a promising avenue for novel stroke treatments.
Further research into EPC-derived factors is warranted to optimize neurorehabilitation strategies.