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Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

What is Cancer?

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...

Cancer Prevention

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Some...

Cancer Therapies

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However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Feb 6, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

Eicosanoids and cancer.

Renata Nascimento Gomes¹, Souza Felipe da Costa¹, Alison Colquhoun¹

¹Departamento de Biologia Celular e do Desenvolvimento, Instituto de Ciencias Biomedicas, Universidade de São Paulo, SP, BR.

Clinics (Sao Paulo, Brazil)

|August 23, 2018

Summary

This summary is machine-generated.

Eicosanoids, derived from fatty acids, significantly impact cancer progression by influencing cell growth and inflammation. Understanding these molecules offers new diagnostic and therapeutic avenues for cancer treatment.

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Area of Science:

Biochemistry
Molecular Biology
Oncology

Background:

Eicosanoids are bioactive lipids regulating crucial cellular functions like proliferation, migration, and inflammation.
Arachidonic acid is a primary precursor for 2-series eicosanoids, generated via cyclooxygenase, lipoxygenase, and P450 pathways.
Inflammation is integral to tumor initiation, promotion, invasion, and metastasis.

Purpose of the Study:

To review the role of prostanoids and lipoxygenase-derived eicosanoids in tumor development and progression.
To highlight how eicosanoids influence cancer cell proliferation, migration, and inflammatory processes.
To explore the potential of eicosanoids as diagnostic/prognostic markers and therapeutic targets in oncology.

Main Methods:

Literature review of studies investigating eicosanoids in cancer.
Analysis of research focusing on cyclooxygenase, lipoxygenase, and P450 pathways in tumorigenesis.
Synthesis of findings on eicosanoid impact on cell proliferation, migration, and inflammation.

Main Results:

Eicosanoids derived from arachidonic acid play a complex role in various cancer stages.
Specific eicosanoids influence cancer cell proliferation, migration, and the tumor microenvironment.
The inflammatory roles of eicosanoids are critical in tumor development and progression.

Conclusions:

Eicosanoids are key mediators in cancer development and progression.
Targeting eicosanoid pathways may offer novel cancer treatment strategies.
Further understanding of eicosanoids can lead to improved cancer diagnostics and prognostics.