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Related Experiment Videos

Oral Immunotherapy Using Partially Hydrolyzed Formula for Cow's Milk Protein Allergy: A Randomized, Controlled Trial.

Chisato Inuo1,2,3, Kenichi Tanaka2, Satoko Suzuki2

  • 1Department of Pediatrics, School of Medicine, Fujita Health University, Toyoake, Japan.

International Archives of Allergy and Immunology
|August 23, 2018
PubMed
Summary

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Partially hydrolyzed formula (pHF) safely enhanced tolerance to cow's milk protein allergy (CMPA) in children. This oral immunotherapy approach, using pHF, showed improved thresholds compared to extensively hydrolyzed formula (eHF).

Area of Science:

  • Pediatric Allergy and Immunology
  • Gastroenterology
  • Immunology

Background:

  • Cow's milk protein allergy (CMPA) affects many children, often necessitating specialized formulas.
  • Partially hydrolyzed formula (pHF) exhibits reduced allergenicity, making it a candidate for oral immunotherapy (OIT).
  • Investigating the safety and efficacy of pHF-based OIT is crucial for managing CMPA.

Purpose of the Study:

  • To evaluate the efficacy and safety of oral immunotherapy using partially hydrolyzed formula (pHF) in children diagnosed with CMPA.
  • To compare the effects of pHF-based OIT with extensively hydrolyzed formula (eHF) in CMPA management.

Main Methods:

  • A randomized, double-blind, controlled trial involving 25 children aged 1-9 years with CMPA.
  • Participants were assigned to either a pHF-pHF group or an eHF-pHF group for initial treatment, followed by an open-label phase with pHF for all.
Keywords:
Cow’s milk protein allergyFood allergyOral immunotherapyPartially hydrolyzed formula

Related Experiment Videos

  • Primary endpoint: change in allergen threshold post-initial phase. Secondary endpoints: changes in thresholds, casein-specific IgE, IgG4, and basophil activation.

    • Main Results:

    • The pHF-pHF group demonstrated a significant elevation in allergen threshold (p = 0.048) after the initial phase, unlike the eHF-pHF group.
    • No significant changes in thresholds were observed between other phases in either group.
    • The eHF-pHF group showed a significant decrease in casein-specific IgE levels (p = 0.014). No severe allergic reactions occurred.

    Conclusions:

    • Partially hydrolyzed formula (pHF) may be a safe and effective option for enhancing tolerance in children with CMPA.
    • pHF-based oral immunotherapy appears to be a viable alternative to eHF for improving cow's milk tolerance.
    • The study supports the use of pHF in OIT protocols for pediatric CMPA.