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Updated: Feb 6, 2026

Harvesting and Disaggregation: An Overlooked Step in Biofilm Methods Research
Published on: April 22, 2022
Design and Assessment of Anti-Biofilm Peptides: Steps Toward Clinical Application
Melanie Dostert1, Corrie R Belanger1, Robert E W Hancock2
1Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
Abstract:
Highly antibiotic resistant, microbial communities, referred to as biofilms, cause various life-threatening infections in humans. At least two-thirds of all clinical infections are biofilm associated, and antibiotic therapy regularly fails to cure patients. Anti-biofilm peptides represent a promising approach to treat these infections by targeting biofilm-specific characteristics such as highly conserved regulatory mechanisms. They are being considered for clinical application and we discuss here key factors in discovery, design, and application, particularly the implementation of host-mimicking conditions, that are required to enable the successful advancement of potent anti-biofilm peptides from the bench to the clinic.
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