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Cell surface markers in leukemia: biological and clinical correlations
Critical Reviews in Oncology/Hematology
|January 1, 1985
Summary
Leukemia cell surface markers aid in understanding differentiation and origin. Phenotyping reveals consistent patterns, improving diagnosis, prognosis, and therapeutic strategies for various leukemias.
Area of Science:
- Immunology
- Hematology
- Oncology
Background:
- Leukocyte differentiation and leukemia origins are elucidated by analyzing cell surface markers.
- Monoclonal antibodies offer precise discrimination of human lymphocyte and granulocyte differentiation stages.
Purpose of the Study:
- To explore detailed phenotypes of leukemic cells in relation to normal hematopoietic differentiation.
- To establish the clinical significance of immunodiagnosis in leukemia classification and prognosis.
- To investigate therapeutic applications of leukemia-associated antigens.
Main Methods:
- Analysis of cell surface markers on leukemic cells.
- Comparison of leukemic cell phenotypes with normal hematopoietic differentiation stages.
- Utilizing monoclonal antibodies for precise cell identification.
Main Results:
- Leukemic cell phenotypes consistently mimic normal cells at equivalent maturation levels.
- Immunodiagnosis improves acute leukemia classification, identifying five major subtypes of acute lymphoblastic leukemia (ALL).
- Classifications based on cell type demonstrate prognostic significance.
Conclusions:
- Leukemia cell phenotyping provides objective diagnostic criteria and prognostically significant subclassifications.
- Monoclonal antibodies are valuable for leukemia classification, therapy (e.g., residual cell lysis), and monitoring differentiation-inducing treatments.