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Related Concept Videos

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Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
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Deprescription in Advanced Cancer Patients.

Ferraz Gonçalves1

  • 1Palliative Care Service, Instituto Português de Oncologia, R. Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal. ferrazg@ipoporto.min-saude.pt.

Pharmacy (Basel, Switzerland)
|August 24, 2018
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Summary

Deprescription, or reducing medications, is a safe and effective strategy to improve patient wellbeing and reduce adverse drug events. This approach, individualized for each patient, can positively impact cognitive function and decrease hospital admissions.

Keywords:
deprescriptioninappropriate medicationpolypharmacy

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Area of Science:

  • Geriatric Medicine
  • Clinical Pharmacy
  • Pharmacology

Background:

  • Polypharmacy, the use of multiple drugs, is common but often lacks precise definition and can lead to inappropriate prescribing.
  • Unwise drug combinations increase adverse reaction risks, and long-term prevention in short-life-expectancy patients offers no benefit.
  • These issues highlight the need for deprescription, the process of reducing or stopping medications.

Purpose of the Study:

  • To introduce and discuss the concept of deprescription as a response to inappropriate polypharmacy.
  • To identify reasons for inappropriate drug prescription and barriers to medication reduction.
  • To propose a structured approach to guide deprescription.

Main Methods:

  • Review of existing literature and concepts surrounding polypharmacy and deprescription.
  • Identification of tools developed to assist prescribers in limiting drug use.
  • Proposal of a six-step method for individualized deprescription.

Main Results:

  • Studies indicate that deprescription is feasible and safe for many patients.
  • Successful deprescription can lead to improvements in wellbeing, cognitive function, and a reduction in falls.
  • Deprescription may also decrease hospital admissions.

Conclusions:

  • Deprescription is a valuable strategy to optimize medication regimens and improve patient outcomes.
  • The process should be individualized and involve shared decision-making with patients and their families.
  • A proposed six-step method provides a framework for implementing deprescription effectively.