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ERBBal Remedies: Combination Therapy for EGFR-mutant Lung Cancers

Pang-Dian Fan1, Helena A Yu2,3

  • 1Department of Pathology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|August 24, 2018
PubMed

Insights

Acquired resistance to EGFR inhibitors in lung cancer is linked to ERBB/HER family kinases. New therapies targeting these kinases are being developed to overcome or prevent this resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Epidermal Growth Factor Receptor (EGFR) inhibitors are crucial for treating EGFR-mutant lung cancers.
  • Acquired resistance to these inhibitors is a significant clinical challenge.
  • Members of the ERBB/HER family of receptor tyrosine kinases are implicated in resistance mechanisms.

Purpose of the Study:

  • To review the role of ERBB/HER family members in acquired resistance to EGFR inhibitors.
  • To discuss emerging single-agent and combination therapies targeting ERBB/HER family members.
  • To explore strategies for preventing or overcoming acquired resistance in EGFR-mutant lung cancer.

Main Methods:

  • Literature review of studies investigating ERBB/HER family kinases in EGFR inhibitor resistance.
  • Analysis of preclinical and clinical data on novel therapeutic strategies.
  • Synthesis of information on targeted therapies and resistance mechanisms.

Main Results:

  • Multiple ERBB/HER family members contribute to acquired resistance to EGFR inhibitors.
  • Targeting these ERBB/HER family members shows promise in preclinical and early clinical studies.
  • Combination therapies may offer enhanced efficacy in overcoming resistance.

Conclusions:

  • Understanding the role of ERBB/HER family kinases is critical for developing effective lung cancer treatments.
  • New therapeutic approaches targeting ERBB/HER family members are essential for managing acquired resistance.
  • Further investigation into these targeted therapies is warranted to improve patient outcomes.

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