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Both maternal and paternal risk factors for term singleton low birthweight infants in rural Chinese population: a

Shi Chen1, Yingying Yang1, Yimin Qu2

  • 1Key Laboratory of Endocrinology of National Health and Family Planning Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.

Scientific Reports
|August 24, 2018
PubMed

Insights

Maternal hepatitis B, irregular folic acid, and paternal varicocele increase low birth weight (LBW) risk in China. Identifying and addressing these parental factors is crucial for improving pregnancy outcomes and infant health.

Area of Science:

  • Obstetrics and Gynecology
  • Pediatrics
  • Public Health

Background:

  • Low birth weight (LBW) remains a significant global health concern.
  • Limited large-scale studies in China have investigated both maternal and paternal risk factors for LBW.

Purpose of the Study:

  • To identify parental risk factors associated with low birth weight (LBW) in a Chinese population.
  • To provide evidence for targeted interventions to improve birth outcomes.

Main Methods:

  • A population-based, retrospective cohort study of 202,725 singleton infants born at 37-42 weeks gestation.
  • Infants classified as LBW (≤2500g) or normal birth weight (50th-97th percentile) based on Chinese norms.
  • Multiple logistic regression analyses used to determine associations between parental factors and LBW.

Main Results:

  • Positive maternal hepatitis B surface antigen (RR=1.979), irregular folic acid intake (RR=1.152), and paternal history of varicocele (RR=2.404) were significantly associated with LBW.
  • Female infants also showed a higher risk of LBW (RR=1.072).
  • Maternal smoking, hypertension, and stillbirth history showed a trend towards association but lacked statistical significance.

Conclusions:

  • Maternal hepatitis B, irregular folic acid intake, and paternal varicocele are significant risk factors for LBW in China.
  • These findings highlight the importance of parental health and specific conditions in influencing infant birth weight.
  • Interventions targeting these factors are recommended to improve pregnancy outcomes and reduce LBW incidence.

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