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Updated: Feb 6, 2026

Isolation of Human Endothelial Cells from Normal Colon and Colorectal Carcinoma - An Improved Protocol
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Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3

Song Wu1, Yuling Qiu2, Yingying Shao1

  • 1Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Frontiers in Pharmacology
|August 24, 2018
PubMed

Insights

Lycorine effectively inhibits Signal Transducer and Activator of Transcription 3 (STAT3) in colon cancer. This natural compound shows anti-cancer effects by inducing apoptosis and reducing tumor growth, offering a potential new therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Signal transducer and activator of transcription 3 (STAT3) is a key regulator in cancer development.
  • Targeting STAT3 offers a promising strategy for cancer therapeutics.

Purpose of the Study:

  • To investigate lycorine as a STAT3 inhibitor for colorectal cancer (CRC) treatment.
  • To elucidate the mechanism of lycorine's anti-cancer activity.

Main Methods:

  • Molecular docking to determine lycorine's binding site on STAT3.
  • In vitro studies on human CRC cells to assess anti-proliferative and apoptotic effects.
  • In vivo xenograft mouse models to evaluate therapeutic potential and toxicity.

Main Results:

  • Lycorine selectively inhibited phospho-STAT3 (Tyr-705) by binding to its SH2 domain.
  • Lycorine demonstrated anti-proliferative activity and induced apoptosis in CRC cells via the mitochondrial pathway.
  • STAT3 overexpression attenuated lycorine's effects, confirming its mechanism of action.
  • Lycorine showed therapeutic efficacy in xenograft models with no observed toxicity.

Conclusions:

  • Lycorine is a potent STAT3 inhibitor with significant anti-tumorigenic effects in colorectal carcinoma.
  • Lycorine represents a promising therapeutic candidate for targeting STAT3 in colon cancer treatment.
Keywords:
STAT3apoptosiscolorectal cancerslycorinetarget

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