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Can Aspirin Minimize Stroke Risk and New Lesion Formation in Multiple Sclerosis?

Jagannadha Avasarala1, Naveen Parti2

  • 1Division of Neurology, Department of Internal Medicine, University of South Carolina School of Medicine, Greeville, SC, United States.

Frontiers in Neurology
|August 24, 2018
PubMed

Insights

The incidence and prevalence of acute stroke in multiple sclerosis (MS) patients remain largely unstudied, despite potential links to venous vascular issues. More research is urgently needed to understand stroke risk in MS populations.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Epidemiology

Background:

  • Increasing data suggest the brain's venous system may play a role in multiple sclerosis (MS).
  • Current diagnostic and treatment protocols do not address the risk of acute stroke in MS patients.
  • The incidence and prevalence of acute stroke in MS patients are not systematically documented.

Purpose of the Study:

  • To highlight the critical gap in understanding acute stroke incidence and prevalence in multiple sclerosis (MS) patients.
  • To emphasize the need for systematic studies investigating the association between acute stroke and MS.
  • To underscore the lack of data regarding demographic factors (age, gender, ethnicity) in acute stroke cases within the MS population.

Main Methods:

  • Review of existing literature on acute stroke in MS patients.
  • Identification of anecdotal reports and limitations in current research.
  • Analysis of diagnostic challenges due to overlapping symptoms of acute stroke and MS flares.

Main Results:

  • A significant lack of large, prospective, multi-center studies on acute stroke incidence in MS patients.
  • Anecdotal reports suggest acute stroke occurs in MS patients, but a fundamental association is not well-established.
  • Overlapping symptoms between acute stroke and MS flares complicate diagnosis, potentially leading to misadministration of treatments like IV alteplase.

Conclusions:

  • There is an urgent need for comprehensive research into the incidence, prevalence, and risk factors of acute stroke in multiple sclerosis.
  • Clear clinical and radiological criteria are required to differentiate acute stroke from MS flares.
  • Clinical trials investigating interventions such as aspirin for MS patients experiencing stroke are essential.

Keywords:
MRI dataaspirinmultiple sclerosisperivenular lesionrelapsestroke

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