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Related Concept Videos

Components of Stress01:23

Components of Stress

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Stress analysis under multiple loading conditions is intricate, necessitating a comprehensive grasp of normal and shearing stresses. Consider a small cube at point O, subjected to stress on all six faces, visible or not. Normal stress components σx, σy, σz act perpendicularly to the x, y, and z axes. Shearing stress components τxy and τxz are exerted on faces perpendicular to these axes.
Interestingly, the hidden cube faces also experience these stresses, equal and...
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Components of Language01:24

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Language, whether spoken, signed, or written, consists of specific components: lexicon and grammar. The lexicon is the vocabulary of a language, comprising its words. Grammar is the set of rules used to convey meaning through the lexicon. For example, English grammar adds “-ed” to most verbs to indicate past tense. Words are formed by combining phonemes, which are the basic sound units of a language. Different languages have different sets of phonemes (e.g., “ah” vs.
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Vector Algebra: Method of Components01:08

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It is cumbersome to find the magnitudes of vectors using the parallelogram rule or using the graphical method to perform mathematical operations like addition, subtraction, and multiplication. There are two ways to circumvent this algebraic complexity. One way is to draw the vectors to scale, as in navigation, and read approximate vector lengths and angles (directions) from the graphs. The other way is to use the method of components.
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Curvilinear motion characterizes the movement of a particle or object along a curved path, notably evident when envisioning a car navigating a winding road. If the car starts at point A, its position vector is established within a fixed frame of reference, where the ratio of the position vector to its magnitude signifies the unit vector pointing in the position vector's direction.
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When drugs enter systemic circulation, they interact with various components of the blood, including proteins such as human serum albumin (HSA), α1-acid glycoprotein (AAG), lipoproteins, globulins, and red blood cells (RBCs).
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The electron transport chain (ETC) is a crucial metabolic pathway that facilitates energy conversion in prokaryotic and eukaryotic cells. In eukaryotes, the ETC comprises four membrane-associated protein complexes in the inner mitochondrial membrane. In prokaryotes, the ETC in the plasma membrane can vary in composition, with fewer or different complexes depending on the organism and environmental conditions. These complexes transfer electrons from electron donors, such as NADH and FADH2, to...
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Related Experiment Video

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Major Components of the Light Microscope
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Epiviz Web Components: reusable and extensible component library to visualize functional genomic datasets.

Jayaram Kancherla1,2, Alexander Zhang3, Brian Gottfried3

  • 1Center for Bioinformatics and Computational Biology, University of Maryland, College Park, College Park, Maryland, 20742, USA.

F1000Research
|August 24, 2018
PubMed
Summary

Researchers developed the Epiviz Component Library for flexible genomic data visualization. This reusable tool simplifies creating custom bioinformatics applications and data analyses.

Keywords:
bioinformaticsepigeneticsgenomicsvisualizationweb components

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomic Data Visualization

Background:

  • Interactive and integrative data visualization tools are crucial for genomic data exploration and analysis.
  • Existing web-based genome browsers are often dataset-specific, limiting integration and extensibility.
  • There is a need for adaptable software libraries to enable customized genomic data viewers and analyses.

Purpose of the Study:

  • To develop a reusable and extensible data visualization library and application framework for genomic data.
  • To leverage recent advances in web platform APIs and technologies, such as Web Components.
  • To simplify the development and management of bioinformatics applications.

Main Methods:

  • Developed the Epiviz Component Library using Web Components and other core web technologies.
  • Designed the library to be modular, reusable, and natively extensible.
  • Created an R/Bioconductor package, epivizrChart, to demonstrate integration with R and Shiny environments.

Main Results:

  • The Epiviz Component Library facilitates the integration of visualizations with various JavaScript libraries and HTML frameworks.
  • The epivizrChart package enables interactive, shareable, and reproducible genomic data visualizations within R, Shiny, and standalone HTML documents.
  • The modular and extensible design simplifies the creation and maintenance of bioinformatics applications.

Conclusions:

  • The Epiviz Component Library offers a flexible and powerful solution for genomic data visualization.
  • It addresses the limitations of existing tools by providing a highly integrable and extensible framework.
  • This library empowers bioinformatic researchers and developers to build customized data analysis and visualization tools more efficiently.