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Emerging of ptxP3 lineage in Bordetella pertussis strains circulating in a population in northeastern Mexico

J L Gutiérrez-Ferman1, L Villarreal-Treviño2, J M Ramírez-Aranda3

  • 1Servicio de Gastroenterología,Hospital Universitario 'Dr José Eleuterio González', Universidad Autónoma de Nuevo León,Monterrey, Nuevo León,México.

Epidemiology and Infection
|August 24, 2018
PubMed

Insights

Molecular epidemiology of Bordetella pertussis in Mexico revealed an endemic clone and three subtypes. These findings, linked to global pertussis outbreaks, suggest a potential impact on the reemergence of whooping cough.

Area of Science:

  • Microbiology
  • Epidemiology
  • Genetics

Background:

  • Pertussis (whooping cough) reemergence is a global public health concern.
  • Understanding the molecular characteristics of Bordetella pertussis is crucial for disease control.

Purpose of the Study:

  • To determine the molecular epidemiology of Bordetella pertussis isolates in Mexico.
  • To evaluate the potential impact of these isolates on pertussis reemergence.

Main Methods:

  • Analysis of 11,864 samples for pertussis infection using culture and real-time PCR.
  • Molecular typing of Bordetella pertussis isolates using pulsed-field gel electrophoresis (PFGE) and PCR sequencing for specific genes (ptxP, ptxA, prn, fim2, fim3).

Main Results:

  • Pertussis was confirmed in 5.8% of samples.
  • One predominant clone (clone A) and three major subtypes (A1, A2, A3) were identified by PFGE.
  • All analyzed isolates possessed the ptxP3-ptxA1 allelic combination, corresponding to emerging genotypes associated with global outbreaks.

Conclusions:

  • An endemic Bordetella pertussis clone and three predominant subtypes were identified in Mexico.
  • These genotypes (ptxP3-ptxA1-prn2-fim2-1-fim3-2 and ptxP3-ptxA1-prn2-fim2-1-fim3-1) are associated with global pertussis outbreaks.
  • The findings support the ongoing global spread of these specific Bordetella pertussis genotypes.
Keywords:
Bordetella pertussisMexicogenotypingptxP3pulsed-field gel electrophoresis

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