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Related Concept Videos

Peripheral Nervous System: Ganglia and Nerves01:24

Peripheral Nervous System: Ganglia and Nerves

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The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
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Spinal Nerves: Plexus II01:21

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The plexuses of the lower body include the lumbar, sacral, and coccygeal plexuses, which innervate the abdomen, pelvis, legs, and coccygeal region. These plexuses control the transmission of sensory information and coordinate motor functions of the lower body.
The Lumbar Plexus
The lumbar plexus is situated within the lumbar region of the back and is primarily formed by the first four lumbar spinal nerves (L1 to L4). This plexus extends its branches into several nerves, including the...
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Nerve Supply of the GI Tract01:27

Nerve Supply of the GI Tract

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The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
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Cranial Nerves: Types Part I01:14

Cranial Nerves: Types Part I

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Cranial nerves are responsible for transmitting motor and sensory information between the brain and various parts of the body. There are twelve pairs of cranial nerves, with the first six being essential in sensory perception, motor control, and autonomic functions related to the head and neck.
Olfactory Nerve (Cranial Nerve I)
The olfactory nerve, or cranial nerve I, is unique as it is purely sensory and dedicated to the sense of smell. This nerve originates in the olfactory epithelium of the...
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Cranial Nerves: Types Part II01:22

Cranial Nerves: Types Part II

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Cranial nerves are responsible for transmitting motor and sensory information between the brain and various parts of the body. There are twelve pairs of cranial nerves. While the first six innervate the head and neck, the latter six nerves innervate the head and neck, as well as organs and tissues in the thoracic and abdominal cavities. They facilitate communication, expression, and autonomic control within the human body.
Facial Nerve (Cranial Nerve VII)
Cranial nerve VII, or the facial nerve,...
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Spinal Nerves: Anatomy01:23

Spinal Nerves: Anatomy

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Spinal nerves are pivotal conduits in the nervous system, bridging the central nervous system (CNS) with the peripheral nervous system (PNS). These nerves enable a complex communication network between the brain, spinal cord, and the rest of the body, facilitating sensory input, motor output, and autonomic functions.
There are 31 bilateral pairs of spinal nerves, each emerging from the spinal cord through the intervertebral foramina—openings between adjacent vertebrae. These nerves are...
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Related Experiment Video

Updated: Feb 6, 2026

Reproducible Mouse Sciatic Nerve Crush and Subsequent Assessment of Regeneration by Whole Mount Muscle Analysis
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Reproducible Mouse Sciatic Nerve Crush and Subsequent Assessment of Regeneration by Whole Mount Muscle Analysis

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Decellularized sciatic nerve matrix as a biodegradable conduit for peripheral nerve regeneration.

Jongbae Choi1, Jun Ho Kim1, Ji Wook Jang1

  • 1R&D Center, Genewel Co., Ltd., Seongnam-si, Gyeonggi-do, Korea.

Neural Regeneration Research
|August 24, 2018
PubMed
Summary

A new biodegradable collagen nerve conduit significantly improves peripheral nerve regeneration in rats. This tissue-engineered solution offers better outcomes than traditional silicone conduits for nerve repair.

Keywords:
biodegradablecollagendecellularizedgrowth factornerve conduitnerve regenerationperipheral nerve injuryrat modelregenerationsilicone conduit

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Axoplasm Isolation from Rat Sciatic Nerve
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The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Neuroscience

Background:

  • Autologous nerve grafts are standard for nerve defects but face limitations like donor site morbidity and tissue availability.
  • Tissue engineering offers nerve conduits as a promising alternative for peripheral nerve repair.
  • Current nerve conduits, like silicone, have limitations in promoting nerve regeneration.

Purpose of the Study:

  • To develop and evaluate a biodegradable, collagen-based nerve conduit for peripheral nerve regeneration.
  • To compare the efficacy of the collagen-based conduit against a silicone conduit and a sham control in a rat sciatic nerve defect model.
  • To assess the structural and biochemical properties of the novel nerve conduit.

Main Methods:

  • A biodegradable collagen-based nerve conduit was fabricated incorporating decellularized sciatic nerve matrix, nerve growth factor, brain-derived neurotrophic factor, and laminin.
  • The conduit's structure was analyzed using scanning electron microscopy.
  • Functional and histological assessments were performed on rats with sciatic nerve defects implanted with the collagen-based conduit, silicone conduit, or sham control.

Main Results:

  • The collagen-based conduit demonstrated a porous inner structure and a protective outer wall, confirmed by scanning electron microscopy.
  • Enzyme-linked immunosorbent assay confirmed the presence of nerve growth factor, brain-derived neurotrophic factor, and laminin within the conduit.
  • Rats treated with the collagen-based conduit showed significantly enhanced motor and sensory nerve function and improved nerve regeneration compared to the silicone conduit and sham groups.

Conclusions:

  • The biodegradable collagen-based nerve conduit effectively promotes peripheral nerve regeneration.
  • This novel conduit demonstrates superior efficacy compared to traditional silicone conduits for bridging nerve defects.
  • The findings support the potential of this engineered nerve conduit as an advanced therapeutic option for nerve repair.