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Published on: May 14, 2020
Modelling the growth of popliteal artery aneurysms
Insights
Popliteal artery aneurysms (PAAs) grow approximately 2.4 mm annually. Patients with abdominal aortic aneurysms (AAAs) experience faster PAA growth, highlighting the importance of monitoring co-existing conditions.
Area of Science:
- Vascular Surgery
- Medical Imaging
- Biostatistics
Background:
- Popliteal artery aneurysms (PAAs) are the most common peripheral aneurysms, yet longitudinal progression data are scarce.
- Understanding PAA growth is crucial for clinical management and predicting outcomes.
Purpose of the Study:
- To track the longitudinal growth of asymptomatic PAAs.
- To compare different models for predicting aneurysm expansion.
- To investigate the influence of abdominal aortic aneurysms (AAAs) on PAA progression.
Main Methods:
- Retrospective single-center cohort study.
- Inclusion of patients with PAAs identified via lower limb arterial duplex ultrasound (2011-2016).
- Linear multilevel modeling to analyze PAA size progression and correlate with AAA presence.
Main Results:
- Analyzed 282 images from 47 limbs with PAAs in 32 patients.
- Estimated average PAA growth rate of 2.4 mm/year.
- Significantly faster PAA growth (3.5 mm/year) observed in patients with existing AAAs compared to those without (0.8 mm/year).
Conclusions:
- Multilevel modeling effectively predicts heterogeneous PAA growth rates.
- Concurrent abdominal aortic aneurysms are associated with accelerated popliteal artery aneurysm progression.
- This finding underscores the need for vigilant monitoring of PAAs in patients with AAAs.
Background:
Popliteal artery aneurysms (PAAs) comprise up to 85 per cent of all peripheral aneurysms. Few longitudinal studies track their progression. This study aimed to track the growth of asymptomatic PAAs in a hospital-based ultrasound service, and compare models of aneurysm growth.
Methods:
This retrospective single-centre cohort study included patients who had a PAA on arterial duplex ultrasound imaging of the lower limbs between 1 January 2011 and 1 January 2016. Progression of PAA size and progression to event or intervention were the primary outcome measures.
Results:
Some 282 images were analysed: 47 limbs with PAA were included in a cohort of 32 patients (15 had bilateral PAAs). Twenty patients also had an abdominal aortic aneurysm (AAA). Linear multilevel modelling estimated that PAA growth was 2·4 (95 per cent c.i. 1·6 to 3·7) mm a year. Growth was estimated at 0·8 (0·1 to 1·5) mm per year in patients without an AAA and 3·5 (2·9 to 4·2) mm per year in those with a known AAA (previous open repair, previous endovascular aneurysm repair or AAA under surveillance) (P < 0·001).
Conclusion:
Growth rates of PAA were heterogeneous but were optimally predicted by multilevel modelling. Patients with an existing AAA may have faster PAA progression than those without.
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