[Trypsic inhibitors in serum and hyaline membrane disease (author's transl)]

Alpha1 antitrypsin (A1AT), alpha2 macroglobulin, alpha, quimotrypsin, interalpha1 antitrypsin and trypsin inhibitory capacity in serum of newborn with hyaline membrane disease, are compared with values obtained in other dis orders, and with normal newborn at different gestacional age. Significant decreased level of A1AT and trypsin inhibitory capacity were found in hyaline membrane patients, that were in order to symptoms severity and time in which samples were obtained. A1AT immunofluorescent study of hyaline membrane in died newborns was positive allowing to explain the low levels found in serum. Presence of fibrine IgG, C1a and C3 in hyaline membrane is according to it's composition by plasmatic components. Thus a new pathogenic mecanisme (derived of the plasma viscosity in the alveolar layer) could be present in hyaline membrane formation.