[MORPHOLOGICAL CHARACTERISTICS OF THE ALLANTOIC PLACENTA IN RATS WITH EXPERIMENTAL LIVER DAMAGE]

The aim of the study was an analysis of the peculiarities of morphological changes of the placenta in rats with experimental chronic hepatic lesion. Liver injury was modeled in 3-month-old sexually mature female rats by 2-fold intragastric administration of paracetamol at a dose of 2.5 g/kg body weight (drug group, n=15) and a single intraperitoneal injection of D-galactosamine at a dose of 250 mg/kg of body weight (toxic group, n=15). Intact rats served as a control. The placenta examined at Day 21 of pregnancy using histological and morphometric methods. Рroliferative activity of placental cells was evaluated with the immunocytochemical method using antibodies against Ki-67 antigen. The membrane permeability in different trophoblast compartments was examined. It was found that experimental chronic liver pathology caused morphological changes in the placenta, which were manifested by a decrease in the area of its labyrinthine portion, maternal sinusoids in the basal area, fetal capillaries and maternal lacunae of the labyrinth. In addition, in the experiments with an intraperitoneal injection of trypan blue it was shown that changes in the liver caused increased permeability of the placental barrier, and reduced the proliferative activity of trophoblast cells.