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Magnetite Nanocontainers: Toward Injectable Highly Magnetic Materials for Targeted Drug Delivery
Elizaveta I Anastasova1, Artur Y Prilepskii1, Anna F Fakhardo1
1Laboratory of Solution Chemistry of Advanced Materials and Technologies , ITMO University , St. Petersburg , 197101 , Russian Federation.
Abstract:
Nanocontainers based solely on magnetite NPs have been synthesized by indirect gelation of stable magnetite hydrosol at ambient temperature using the microemulsion-assisted sol-gel method. Containers synthesized have adjustable size and consist of ∼10 nm magnetite nanoparticles linked by Fe-O-Fe interparticle bonds. The material demonstrates high magnetization values up to 60 emu/g and low cytotoxicity against both HeLa and postnatal human fibroblast (up to 260 μg/mL). The systems developed are perspective as a drug depot, particularly for magnetically controlled thrombolysis.
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