Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Thin-Layer Chromatography (TLC): Overview01:11

Thin-Layer Chromatography (TLC): Overview

4.8K
Thin-layer chromatography (TLC) is a chromatography technique that separates compounds based on their polarity. TLC typically uses polar silica gel, a form of silicon dioxide, as the stationary phase. The silica gel contains hydroxyl (OH) groups on its surface, which form hydrogen bonds with polar compounds, influencing their adhesion to the stationary phase.
To begin the analysis, a mixture of compounds is spotted on the starting line on the TLC plate using a thin capillary. The bottom of the...
4.8K
Binet's Contribution to Measures of Intelligence01:23

Binet's Contribution to Measures of Intelligence

1.7K
Alfred Binet, along with his student Théophile Simon, was tasked by the French Ministry of Education in 1904 to create a method for identifying students who struggled to learn through conventional classroom instruction. This initiative aimed to address overcrowding by placing such students in specialized schools. Binet and Simon developed an intelligence test comprising 30 tasks, ranging from simple commands, like touching one's nose or ear, to more complex tasks, such as drawing...
1.7K
Structural Protein Function01:56

Structural Protein Function

30.0K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
30.0K
Aging01:26

Aging

713
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
713
Wechsler's Contribution to Measures of Intelligence01:23

Wechsler's Contribution to Measures of Intelligence

2.1K
David Wechsler, a psychologist who worked with World War I veterans, developed a significant IQ test in 1939 called the Wechsler-Bellevue Intelligence Scale. This test was innovative because it combined several subtests that measured both verbal and nonverbal skills, reflecting Wechsler's belief that intelligence is a global capacity involving purposeful action, rational thinking, and effective interaction with the environment. This test later evolved into the Wechsler Adult Intelligence...
2.1K
Suctioning the Nasopharyngeal Airway01:29

Suctioning the Nasopharyngeal Airway

3.5K
Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementing Digital Respiratory Technologies for People With Respiratory Conditions: Scoping Review.

Journal of medical Internet research·2026
Same author

Predicting clinical exacerbations using respiratory oscillometry during home telemonitoring of patients taking medium-/high-dose asthma treatment.

ERJ open research·2026
Same author

Association between impulse oscillometry Z-scores and asthma control and exacerbation risk in a tertiary severe asthma clinic.

Frontiers in allergy·2026
Same author

The modified in Manila Medical Research Council dyspnoea scale.

The Lancet. Respiratory medicine·2026
Same author

One-year lung function change and variability post allogeneic hematopoietic stem cell transplantation.

Respiratory medicine·2026
Same author

A Screening Test to Identify Individual Susceptibility to Oxidant-Induced Respiratory Epithelial Injury.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Thoroughbred horses susceptible to Recurrent Exertional Rhabdomyolysis have elevated skeletal muscle mitochondrial capacities.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Change in Neutrophil-to-Lymphocyte Ratio after acute and chronic exercise: A Systematic Review and Meta-Analysis.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Ankylosing spondylitis and muscle sympathetic nerve activity: a case study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Intracranial vasomotor and blood flow responses to light intensity aerobic exercise in young adults: a 4D flow MRI study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Comparative assessments of the COSMED adaptive mixing chamber vs. breath-by-breath methods for oxygen uptake measurements in recreationally active adults.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Can we assess exercise metabolism from skin? Metabolomic profiles in skin dialysate collected during exercise.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
See all related articles

Related Experiment Video

Updated: Feb 6, 2026

Estimating the Yield of Compounds on the TLC Plate via the Blue-LED Illumination Technique
06:14

Estimating the Yield of Compounds on the TLC Plate via the Blue-LED Illumination Technique

Published on: October 6, 2022

2.3K

Contribution of peripheral airway function to changes in FEV1/FVC and RV/TLC with aging.

Christopher Htun1,2,3, Alun Pope4, Samir Lahzami5

  • 1The Woolcock Institute of Medical Research, The University of Sydney, Glebe, NSW, Australia.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|August 24, 2018
PubMed
Summary
This summary is machine-generated.

Peripheral airway function significantly impacts lung function changes with aging. Multiple breath nitrogen washout (MBNW) indices correlate with expiratory airflow and gas trapping, especially in older adults.

Keywords:
aging lungmultiple breath nitrogen washoutperipheral airwaysventilation heterogeneity

More Related Videos

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium
07:40

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium

Published on: February 21, 2025

1.3K
Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.2K

Related Experiment Videos

Last Updated: Feb 6, 2026

Estimating the Yield of Compounds on the TLC Plate via the Blue-LED Illumination Technique
06:14

Estimating the Yield of Compounds on the TLC Plate via the Blue-LED Illumination Technique

Published on: October 6, 2022

2.3K
Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium
07:40

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium

Published on: February 21, 2025

1.3K
Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.2K

Area of Science:

  • Pulmonary Physiology
  • Respiratory Medicine
  • Aging Research

Background:

  • Aging affects lung function, particularly peripheral airways, but its impact on standard pulmonary indices is not fully understood.
  • Multiple breath nitrogen washout (MBNW) offers insights into ventilation heterogeneity, including acinar (Sacin) and conducting (Scond) airways.

Purpose of the Study:

  • To investigate the association between MBNW indices and standard pulmonary function tests (PFTs) like FEV1/FVC and RV/TLC in healthy adults.
  • To determine if these associations differ between younger (<50 years) and older (≥50 years) adults.

Main Methods:

  • Seventy-nine healthy adults (23-89 years) underwent spirometry, plethysmography, and MBNW.
  • Statistical analyses adjusted for sex, height, and BMI to examine relationships between MBNW indices (Sacin, Scond, LCI) and PFTs (FEV1/FVC, RV/TLC).

Main Results:

  • Sacin was inversely related to FEV1/FVC and positively related to RV/TLC across all participants.
  • These relationships were more pronounced in older adults, with Sacin showing a stronger inverse link to FEV1/FVC and a positive link to RV/TLC.
  • No significant associations were found between LCI and FEV1/FVC or RV/TLC.

Conclusions:

  • Peripheral airway function, as measured by Sacin and Scond, contributes to age-related changes in FEV1/FVC and RV/TLC.
  • MBNW indices, particularly Sacin, are valuable in assessing age-related lung function decline and may aid in understanding obstructive airway diseases.