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Amyloid Fibrils03:03

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Related Experiment Video

Updated: Feb 6, 2026

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
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Sleep moderates the relationship between amyloid beta and memory recall.

Kristine A Wilckens1, Dana L Tudorascu2, Beth E Snitz3

  • 1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Neurobiology of Aging
|August 24, 2018
PubMed
Summary

Poor sleep exacerbates memory decline in older adults with amyloid-beta (Aβ) accumulation, suggesting sleep may protect against Alzheimer's disease symptoms. Improving sleep could mitigate cognitive impairments associated with Aβ buildup.

Keywords:
Amyloid-βMild cognitive impairmentNeuropsychological performancePreclinical Alzheimer's diseaseSleep

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Area of Science:

  • Neuroscience
  • Gerontology
  • Sleep Medicine

Background:

  • Amyloid-beta (Aβ) accumulation is a key marker in Alzheimer's disease (AD).
  • Aβ alone may not fully explain cognitive decline; other factors like sleep may play a role.
  • Modifiable health behaviors, such as sleep, might influence neurodegeneration symptoms.

Purpose of the Study:

  • To investigate if sleep quality moderates the association between amyloid-beta (Aβ) levels and cognitive performance in older adults.
  • To explore the potential protective role of sleep in mitigating cognitive deficits linked to Aβ.

Main Methods:

  • Study included 41 older adults (mean age 83 years).
  • Sleep was measured using actigraphy (wake after sleep onset, total sleep time).
  • Cognitive functions (memory recall, flexibility, verbal fluency) and Aβ levels (using Pittsburgh Compound B) were assessed.

Main Results:

  • Wake after sleep onset significantly moderated the relationship between Aβ and memory recall.
  • A stronger positive association between Aβ and memory impairment was observed in individuals with poorer sleep quality (higher wake after sleep onset).

Conclusions:

  • Sleep disturbances, specifically increased wakefulness after sleep onset, may worsen memory problems in the presence of amyloid-beta.
  • Adequate sleep may offer a protective effect against cognitive decline in preclinical Alzheimer's disease.