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Conjugated Proteins02:50

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Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
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Chemical reactions, such as those that occur when you light a match, involve changes in energy as well as matter.
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Conjugation01:19

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Conjugation is a form of horizontal gene transfer that primarily occurs in bacteria and some archaea, promoting genetic diversity and adaptation. Bacteria can acquire resistance genes through conjugative plasmids, allowing them to survive antibiotic treatments that would otherwise be lethal. This process involves direct contact between cells through specialized structures such as the sex pilus and is mediated by conjugative plasmids, including the F (fertility) factor.Conjugation requires...
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Bacterial conjugation is a mechanism of horizontal gene transfer that enables the exchange of genetic material between bacterial cells through direct contact. This process is facilitated by a donor cell carrying a conjugative plasmid, which encodes genes necessary for pilus formation, DNA replication, and transfer. The conjugative plasmid plays a central role in initiating and executing the transfer of genetic material.The tra region of the conjugative plasmid encodes proteins responsible for...
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Basicity of Aliphatic Amines01:21

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Related Experiment Video

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Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis
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A basic insight into aptamer-drug conjugates (ApDCs).

Wenjing Xuan1, Yongbo Peng1, Zhengyu Deng1

  • 1Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China.

Biomaterials
|August 24, 2018
PubMed
Summary
This summary is machine-generated.

Aptamer-drug conjugates (ApDCs) offer advantages over antibodies for cancer therapy, addressing challenges in stability and safety for clinical use.

Keywords:
Aptamer-drug conjugates (ApDCs)AptamersCell-SELEXTargeted therapy

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Aptamers are recognized as effective targeting ligands for cancer cell detection, similar to antibodies.
  • Aptamers possess advantageous properties such as small size, chemical stability, and low immunogenicity compared to antibodies.
  • Clinical translation of aptamers has been hindered by concerns regarding their physicochemical stability and safety.

Purpose of the Study:

  • To review the development of aptamer-drug conjugates (ApDCs).
  • To discuss strategies for overcoming challenges in the clinical application of ApDCs for targeted cancer therapy.

Main Methods:

  • Literature review of aptamer and ApDC development.
  • Analysis of strategies to enhance aptamer stability and safety.
  • Discussion of clinical translation hurdles and solutions.

Main Results:

  • ApDCs are emerging as a clinically viable tool for targeted cancer therapy.
  • Research is actively addressing stability and safety concerns associated with aptamers.
  • Engineered aptamers and conjugation strategies are improving ApDC efficacy.

Conclusions:

  • ApDCs represent a promising advancement in targeted cancer therapy.
  • Ongoing research is paving the way for the successful clinical application of aptamers.
  • Overcoming stability and safety issues is key to realizing the full potential of ApDCs in oncology.