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Synthesis and Characterization of Amphiphilic Gold Nanoparticles
Published on: July 2, 2019
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Amphiphilic core-shell nanoparticles: Synthesis, biophysical properties, and applications
Raju Panday1, Abhishek Jung Poudel2, Xiaohong Li2
1Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China; Biology Unit, National Forensic Science Laboratory, Kathmandu 44600, Nepal.
Colloids and Surfaces. B, Biointerfaces
|August 24, 2018
Summary
Amphiphilic core shell (ACS) nanoparticles offer versatile, multifunctional nanocarriers for diverse applications. This review details their synthesis, characteristics, and use in drug/gene co-delivery and non-medical fields.
Area of Science:
- Materials Science
- Nanotechnology
- Polymer Chemistry
Background:
- Amphiphilic core shell (ACS) nanoparticles are advanced nanocarriers synthesized from organic/organic or organic/inorganic materials.
- Their properties, including size, shape, biocompatibility, and biodegradability, are tunable via synthesis methods and polymer selection.
Purpose of the Study:
- To review current synthesis methods and biophysical characteristics of polymer-based ACS nanoparticles.
- To elaborate on the applications of ACS nanoparticles in both biomedical and non-medical fields.
- To highlight the potential of ACS nanoparticles in drug and gene co-delivery systems.
Main Methods:
- Review of existing literature on ACS nanoparticle synthesis and characterization.
- Analysis of studies detailing ACS nanoparticle applications in various fields.
- Focus on recent advancements in drug and gene co-delivery using ACS nanoparticles.
Main Results:
- ACS nanoparticles demonstrate versatility as drug and gene carriers, with some undergoing human trials.
- Non-medical applications include enzyme immobilization, bioseparation, heavy metal removal, and toxic gas remediation.
- Synthesis and polymer chemistry influence nanoparticle design for enhanced therapeutic delivery.
Conclusions:
- Novel multifunctional ACS nanoparticles hold significant promise for delivering complex therapeutic molecules.
- Optimized carrier design and polymer chemistry are crucial for future advancements.
- ACS nanoparticles represent a key platform for next-generation drug and gene delivery systems.
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