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Single oral high-dose vitamin D3 prophylaxis in the elderly
Journal of the American Geriatrics Society
|July 1, 1986
Summary
A single high dose of vitamin D3 is a safe and effective way to prevent vitamin D deficiency in the elderly, especially during winter months. This method offers a simple prophylaxis for senile osteopenia.
Area of Science:
- Gerontology
- Nutritional Science
- Endocrinology
Background:
- Vitamin D deficiency is prevalent in older adults, particularly during winter.
- Hypovitaminosis D is a potential contributor to senile osteopenia.
- Effective prophylactic strategies are needed for this demographic.
Purpose of the Study:
- To compare the efficacy of vitamin D3 versus 25-hydroxyvitamin D3 (25-OHD3) for prophylaxis in the elderly.
- To evaluate a single, oral, high-dose administration method.
- To assess long-term serum 25-OHD levels after supplementation.
Main Methods:
- A comparative trial was conducted in two old-age homes.
- Participants received either a single oral dose of vitamin D3 or 25-OHD3.
- Serum 25-OHD levels were monitored at baseline, peak, and follow-up (4-5 months).
Main Results:
- 25-OHD3 produced a higher peak serum 25-OHD level in the second week compared to vitamin D3.
- After 4-5 months, serum 25-OHD levels in the 25-OHD3 group returned to baseline.
- In the vitamin D3 group, serum 25-OHD levels remained significantly elevated and within normal limits post-supplementation.
Conclusions:
- Single, oral, high-dose vitamin D3 is a safe and simple prophylactic method for the elderly.
- This approach can be easily implemented for large elderly populations.
- Vitamin D3 supplementation provides a more sustained increase in serum 25-OHD levels compared to 25-OHD3.