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Antitumor effects of anlotinib in thyroid cancer

Xianhui Ruan1, Xianle Shi2, Qiman Dong2

  • 1Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.

Endocrine-Related Cancer
|August 25, 2018
PubMed

Insights

Anlotinib, a multi-kinase inhibitor, effectively combats poorly differentiated papillary thyroid cancer and anaplastic thyroid cancer (ATC) by inhibiting cell viability and tumor growth. This study suggests anlotinib as a promising therapeutic strategy for advanced thyroid cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Anaplastic thyroid cancer (ATC) and poorly differentiated papillary thyroid cancer lack effective treatments.
  • Anlotinib, a multi-kinase inhibitor, has demonstrated antitumor activity in other cancers.

Purpose of the Study:

  • To investigate the in vitro and in vivo efficacy of anlotinib against thyroid carcinoma cells.
  • To explore the molecular mechanisms underlying anlotinib's anti-cancer effects in thyroid cancer.

Main Methods:

  • In vitro studies using papillary thyroid cancer and ATC cell lines.
  • In vivo studies involving xenograft mouse models.
  • Analysis of cell viability, migration, cell cycle, and protein expression.

Main Results:

  • Anlotinib significantly inhibited thyroid cancer cell viability and migration in vitro.
  • Anlotinib treatment led to abnormal spindle assembly, G2/M cell cycle arrest, and TP53 activation.
  • Anlotinib suppressed the growth of thyroid cancer xenograft tumors in mice.

Conclusions:

  • Anlotinib exhibits significant anticancer activity against papillary thyroid cancer and ATC.
  • Anlotinib demonstrates potential as a novel therapeutic strategy for advanced thyroid cancer.
Keywords:
anlotinibapoptosismigrationmulti-kinase inhibitorthyroid cancer

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