Related Experiment Video

Updated: Feb 6, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

4.7K

Effects of menaquinone-7 supplementation in patients with aortic valve calcification: study protocol for a randomised

Jes Sanddal Lindholt1,2, Niels Erik Frandsen3, Maise Høigaard Fredgart4

  • 1Department of Cardiothoracic and Vascular Surgery, Odense Universitetshospital, Odense, Denmark.

BMJ Open
|August 25, 2018
PubMed

Insights

This study investigated if menaquinone-7 (MK-7) supplementation slows aortic valve calcification (AVC) progression in older men. Results will determine if MK-7 offers a new preventive strategy for this common heart valve disease.

Area of Science:

  • Cardiology
  • Nutritional Science
  • Medical Research

Background:

  • Aortic stenosis is a prevalent heart valve disease, increasing with the aging population.
  • Current treatment for aortic stenosis is primarily surgical, with limited medical preventive options.
  • Aortic valve calcification (AVC) is a progressive feature of aortic stenosis.

Purpose of the Study:

  • To evaluate the effect of menaquinone-7 (MK-7) supplementation on the progression of aortic valve calcification (AVC).
  • To test the hypothesis that MK-7 slows down the calcification process in the aortic valve.

Main Methods:

  • A multicenter, double-blinded, placebo-controlled study involving 400 men aged 65-74 years with substantial AVC.
  • Participants received either MK-7 (720 µg/day) plus vitamin D (25 µg/day) or a placebo for 2 years.
  • Aortic valve calcification (AVC) scores were assessed using non-contrast CT scans at baseline and 12/24 months.

Main Results:

  • The primary outcome is the difference in AVC score from baseline to 2-year follow-up.
  • Intention-to-treat analysis will be used for all outcome assessments.
  • No adverse effects of MK-7 are reported in the study protocol.

Conclusions:

  • The study aims to determine if MK-7 supplementation can be a viable medical intervention to slow AVC progression.
  • Findings will contribute to understanding potential non-surgical treatments for aortic stenosis.
  • The study adheres to ethical guidelines and will report all findings.
Abstract

Keywords:
aortic valve calcificationcardiovascular imagingmenaquinone-7randomized clinical trialvalvular heart disease

More Related Videos

Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification08:55

Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification

Published on: November 20, 2017

10.3K
Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat04:30

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

3.7K

Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
239
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
474
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K
Trial and Error and Algorithm01:12

Trial and Error and Algorithm

A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
424
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.8K
Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
12.2K