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Related Experiment Video

Updated: Feb 6, 2026

Synthesis of Functionalized Magnetic Nanoparticles, Their Conjugation with the Siderophore Feroxamine and its Evaluation for Bacteria Detection

Synthesis of Functionalized Magnetic Nanoparticles, Their Conjugation with the Siderophore Feroxamine and its Evaluation for Bacteria Detection

Published on: June 16, 2020

Nanoparticle architecture preserves magnetic properties during coating to enable robust multi-modal functionality.

Lauren E Woodard¹, Cindi L Dennis², Julie A Borchers³

¹Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, 21218, USA.

Scientific Reports

|August 25, 2018

Summary

We developed novel iron oxide/silica/gold core-shell nanoparticles. This coating preserves magnetic properties while enhancing imaging and laser heating capabilities for nanomedicine applications.

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Area of Science:

Nanomedicine
Materials Science
Nanotechnology

Background:

Magnetic iron oxide nanoparticles (MIONs) are promising for diagnosis and therapy but have challenging surfaces for functionalization.
Coating MIONs with materials like gold can improve ligand attachment but may compromise magnetic properties or core integrity.
Existing methods face challenges with incomplete coatings or altered magnetic performance.

Purpose of the Study:

To synthesize and characterize iron oxide/silica/gold core-shell nanoparticles.
To investigate the impact of a silica-gold coating process on nanoparticle performance.
To understand how the coating affects magnetic properties, imaging, and therapeutic potential.

Main Methods:

Synthesis of core-shell nanoparticles with iron oxide core, silica intermediate layer, and gold shell.
Characterization using small angle neutron scattering (SANS) to analyze structural intercalation.
Evaluation of magnetic heating properties and X-ray contrast capabilities.

Main Results:

Small angle neutron scattering confirmed silica intercalation within the iron oxide core.
The silica-gold coating formed a continuous shell without exposing the iron oxide core.
The core-shell nanoparticles retained magnetic heating properties similar to the original MIONs.
Enhanced X-ray contrast and laser heating capabilities were observed.

Conclusions:

The developed iron oxide/silica/gold core-shell nanoparticles offer a stable platform for nanomedicine.
The silica interlayer is crucial for preserving magnetic properties while enabling a continuous gold shell.
These nanoparticles present improved functionality for combined diagnostic and therapeutic applications.