Correction: Wild-type and mutated IDH1/2 enzymes and therapy responses

Area of Science:

• Biochemistry
• Cellular Metabolism
• Oncology

Background:

• Isocitrate dehydrogenase (IDH) mutations are common in various cancers.
• IDH mutations alter cellular metabolism, including redox balance.
• Accurate representation of biochemical pathways is critical for understanding disease mechanisms.

Purpose of the Study:

• To correct a factual error in a published scientific figure.
• To ensure accurate representation of the NADPH/NADP+ redox state in IDH-mutated cells.
• To provide reliable data for researchers studying IDH-mutated cancers.

Main Methods:

• Identification of an error in Figure 2 of the original publication.
• Correction of the 'NADP+ ->NADPH' label to 'NADPH ->NADP+' on the IDH1/2 mutated arrow.
• Updating the PDF and HTML versions of the article to reflect the correction.

Main Results:

• The biochemical pathway arrow in Figure 2 has been corrected.
• The corrected arrow accurately depicts the conversion of NADPH to NADP+ in IDH1/2 mutated cells.
• The corrected figure is now available in updated versions of the article.

Conclusions:

• The correction ensures the figure accurately reflects the altered redox state in IDH-mutated cancers.
• This ensures the integrity of the published data for future research.
• The authors apologize for any inconvenience caused by the original error.