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Updated: Feb 6, 2026

Differentiation Capacity of Human Aortic Perivascular Adipose Progenitor Cells
Published on: March 5, 2019
WNT16 induces proliferation and osteogenic differentiation of human perivascular stem cells
Carolyn A Meyers1, Jia Shen2, Amy Lu1
1Department of Pathology, Johns Hopkins University, 21205, USA.
Abstract:
Perivascular stem cells (PSC) are a progenitor population defined by their perivascular residence. Recent studies have examined the relative difference in Wnt ligands to induce PSC differentiation, including Wnt16. Here, we examine the role of Wnt16 in the proliferation and osteogenic differentiation of human PSC. Treatment of PSC with WNT16 significantly increased cell proliferation to a greater extent than did WNT3A. In addition, WNT16 showed a significant increase in osteogenic gene expression among PSC. These data demonstrate that WNT16 represents a combined mitogenic/pro-osteogenic stimulus that may play a functional role in human mesenchymal stem cell mediated bone repair.
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