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Enhancing and Extending Biological Performance and Resilience.

Rehana K Leak1, Edward J Calabrese2, Walter J Kozumbo3

  • 1Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, USA.

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|August 25, 2018
PubMed
Summary

This study explores enhancing human performance and resilience by optimizing biological limits. It proposes novel research directions focusing on stimulus timing and dose to improve health and longevity.

Keywords:
J-shapedU-shapedadaptationbiphasiccaloric restrictionconditioningdietary restrictiondose–responseenduranceepigeneticsfitnesshormesispreconditioningstresstolerance

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Area of Science:

  • Exercise Physiology
  • Biotechnology
  • Human Performance Optimization

Background:

  • Human biological limits for performance, endurance, and resilience are genetically influenced but potentially optimizable.
  • Limited rigorous research exists on methods to systematically enhance these biological maxima.
  • Understanding endogenous defense mechanisms is key to improving tissue structure and function.

Purpose of the Study:

  • To synthesize and critically analyze existing research on endogenous defenses.
  • To generate novel ideas for augmenting biological performance and resilience.
  • To propose specific research recommendations for optimizing protocols that support human health and longevity.

Main Methods:

  • Review and synthesis of published work on endogenous defenses.
  • Analysis of concepts related to conditioning, hormesis, and stress adaptation.
  • Development of recommendations for experimental design, including stimulus parameters and measurement timing.

Main Results:

  • Established methods for exploiting endogenous defense mechanisms are presented.
  • A framework for augmenting biological performance and resilience is discussed.
  • Specific recommendations are provided for researchers to explore stimulus dose-response and temporal dynamics.

Conclusions:

  • Optimizing biological limits requires systematic investigation of stimulus parameters and temporal dimensions.
  • This research path can accelerate the discovery of methods to enhance human health, longevity, and performance.
  • The findings aim to overcome previously intractable constraints on human capabilities.