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Computed Tomography Enterography: Quantitative Evaluation on Crohn's Disease Activity.

Jingyun Cheng¹, Hui Xie¹, Hao Yang¹

¹Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province 430071, China.

Gastroenterology Research and Practice

|August 25, 2018

Summary

Computed tomography enterography (CTE) can quantitatively evaluate Crohn's disease (CD) activity. Key imaging features like bowel wall thickening and hyperenhancement serve as potential biomarkers for CD lesions.

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Area of Science:

Gastroenterology
Radiology
Medical Imaging

Background:

Crohn's disease (CD) activity assessment is crucial for treatment.
Endoscopic evaluation can be invasive and may not fully capture disease extent.
Quantitative imaging biomarkers are needed for objective disease monitoring.

Purpose of the Study:

To assess the feasibility of computed tomography enterography (CTE) for quantitative evaluation of Crohn's disease activity.
To identify imaging features on CTE that correlate with disease severity.

Main Methods:

Retrospective analysis of 49 Crohn's disease patients with clinical, enteroscopy, and CTE data.
Patients were categorized into inactive, mild, and moderate-severe groups based on the simplified endoscopic activity score for Crohn's disease (SES-CD).
Bowel wall thickening, mural hyperenhancement, and ΔCT values were analyzed and correlated with SES-CD, CRP, and ESR.

Main Results:

Significant differences in bowel wall thickening, mural hyperenhancement, and ΔCT values were observed across disease activity groups (P < 0.001).
These imaging parameters showed moderate correlations with SES-CD (r = 0.533–0.585, P < 0.001).
Bowel wall thickening, mural hyperenhancement, and ΔCT values were significantly different among inactive, mild, and moderate-severe CD groups.

Conclusions:

Mural hyperenhancement in the portal vein period, bowel wall thickening, and ΔCT value are accurate quantitative measures of CD activity.
These CTE-derived parameters show potential as visual biomarkers for assessing Crohn's disease lesions.