S-100 protein and myoepithelial neoplasms

Besides advancing our knowledge of histogenesis, immuno-cytochemical studies of salivary gland tumors have added an important objective component to the diagnosis and classification of the tumors. Cellular localization of S-100 protein now allows identification of myoepithelial cells and tumors composed of these cells. The four tumors presented in this report illustrate the diagnostic advantages afforded by S-100 protein immunocytochemistry.