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Interaction of viral oncogenic proteins with the Wnt signaling pathway

Sayyad Khanizadeh1,2, Banafsheh Hasanvand1, Hamed Esmaeil Lashgarian1

  • 1Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

Iranian Journal of Basic Medical Sciences
|August 25, 2018
PubMed

Insights

Viruses contribute to 20% of human cancers by producing oncoproteins that disrupt cell cycles. This review explores how oncogenic viruses interact with the Wnt signaling pathway, a key player in tumor development.

Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • Viruses are estimated to cause up to 20% of human cancers globally.
  • Oncogenic viruses possess genes encoding oncoproteins that drive cell proliferation and transformation.
  • Viral modulation of cellular signaling pathways, particularly the Wnt pathway, is crucial in viral carcinogenesis.

Purpose of the Study:

  • To review the interactions between human oncogenic viral proteins and the Wnt signaling pathway.
  • To highlight the Wnt signaling pathway's central role in tumor development and viral carcinogenesis.

Main Methods:

  • Literature review focusing on viral proteins and Wnt pathway interactions.
  • Analysis of the role of Wnt signaling in viral-induced cancers.

Main Results:

  • Oncogenic viruses frequently modulate the canonical Wnt/β-catenin signaling pathway.
  • Specific viral oncoproteins interact with components of the Wnt pathway to promote cell transformation.
  • The Wnt pathway is a critical target for viral-induced carcinogenesis.

Conclusions:

  • Understanding viral interactions with the Wnt pathway is key to deciphering viral carcinogenesis.
  • Targeting Wnt signaling could offer therapeutic strategies against virus-associated cancers.
Keywords:
Canonical pathwayCarcinogenesisOncogenic virusesWnt signalingβ-catenin

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