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Successful treatment of C. auris shunt infection with intraventricular caspofungin

Tanu Singhal1, Abhaya Kumar1, Prashant Borade1

  • 1Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai 400053, India.

Medical Mycology Case Reports
|August 25, 2018
PubMed

Insights

A rare Candida auris central nervous system infection in an adult was successfully treated with intraventricular caspofungin and systemic voriconazole after other antifungals failed.

Area of Science:

  • Infectious Diseases
  • Mycology
  • Neuroscience

Background:

  • Candida auris is a multidrug-resistant fungal pathogen causing invasive infections.
  • Central nervous system (CNS) infections by Candida auris are rare and challenging to treat.

Observation:

  • An adult patient developed a nosocomial cerebrospinal fluid (CSF) shunt infection due to multidrug-resistant Candida auris.
  • Initial systemic therapy with echinocandin and flucytosine was ineffective.

Findings:

  • Daily intraventricular caspofungin (10 mg) combined with systemic voriconazole achieved clinical and microbiological cure.
  • This regimen demonstrated efficacy in a refractory case of Candida auris CNS infection.

Implications:

  • Intraventricular caspofungin may be a viable salvage therapy for resistant Candida auris CNS infections.
  • Highlights the need for novel treatment strategies against emerging multidrug-resistant fungi.
  • Emphasizes the importance of considering targeted intraventricular therapy for complex CNS fungal infections.
Keywords:
C. aurisCSF shuntIntraventricular caspofungin

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