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Updated: Feb 6, 2026

Layer-by-layer Collagen Deposition in Microfluidic Devices for Microtissue Stabilization
Published on: September 29, 2015
Patch graft using collagen matrix (Ologen) for glaucoma drainage device exposure in a patient with Boston
Samir Jabbour1, Mark R Lesk1,2, Mona Harissi-Dagher1,3
1Department of Ophthalmology, Université de Montréal, Montreal, QC, Canada.
Purpose:
To report the first successfully treated case of recurrent tube exposure in a patient with the Boston Keratoprosthesis type 1 with a collagen matrix patch graft (Ologen).
Observations:
A 50 year-old female with a Boston Keratoprosthesis type 1 and a history of Axenfeld-Reiger syndrome presents to our department with recurrent glaucoma drainage device exposure in her left eye. After failed spontaneous closure with topical antibiotics and lubricants, she undergoes tube exposure repair using an Ologen patch graft. Surgery was successful and the patient did not have any recurrence up to last follow-up two years post-operatively.
Conclusion:
Collagen matrix patch graft seems to be advantageous in treating glaucoma tube exposure in the Boston KPro eye, which is often a more challenging entity to treat.
Importance:
Collagen matrix patch graft could be considered as a primary patch graft in treating tube exposure in eyes with the Boston KPro.
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