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Updated: Feb 6, 2026
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Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
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Meningeal Immunity, Drainage, and Tertiary Lymphoid Structure Formation
1Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, USA. al2hk@virginia.edu.
Methods in Molecular Biology (Clifton, N.J.)
|August 25, 2018
Summary
The brain
Area of Science:
- Neuroimmunology
- Central Nervous System Immunity
Background:
- The brain was traditionally viewed as immune-privileged, with immune cell presence indicating pathology.
- Recent research challenges this notion, revealing the immune system's role in normal brain function.
Purpose of the Study:
- To review advances in understanding brain immunity.
- To explore the generation of tertiary lymphoid structures in the central nervous system (CNS).
Main Methods:
- Literature review of neuroimmunology research.
- Discussion of emerging concepts in CNS immune surveillance.
Main Results:
- Accumulating evidence supports immune system involvement in brain function.
- Tertiary lymphoid structures can form within the CNS.
Conclusions:
- The brain's immune privilege is a dynamic concept.
- Understanding CNS immunity offers potential therapeutic targets for neurological disorders.
- Tertiary lymphoid structures in the CNS may represent a novel therapeutic avenue.
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