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Updated: Feb 6, 2026
07:24
Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
Published on: April 8, 2013
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Adipose-derived cells improve left ventricular diastolic function and increase microvascular perfusion in advanced
Natia Q Kelm1, Jason E Beare1,2, Fangping Yuan1
1Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky, United States of America.
Plos One
|August 25, 2018
Summary
Intravenous injection of stromal vascular fraction (SVF) cells improved coronary microvascular dysfunction and diastolic function in aged rats. This cell therapy offers a potential treatment for age-related cardiac issues without increasing mortality.
Area of Science:
- Cardiovascular Research
- Regenerative Medicine
- Aging Biology
Background:
- Coronary artery disease in older adults often manifests as microvascular dysfunction and diastolic dysfunction.
- Previous studies showed adipose-derived stromal vascular fraction (SVF) preserves microvascular function and intravenous (i.v.) delivery promotes cell migration and vasomotor tone reset.
Purpose of the Study:
- To investigate if i.v. injection of SVF can reverse age-related coronary microvascular dysfunction in a rodent model.
- To assess the efficacy of SVF in improving cardiac function and coronary blood flow in aged rats.
Main Methods:
- Fischer 344 rats were assigned to young control, old control, old + rat aortic endothelial cells, or old + GFP+ SVF groups.
- Cardiac function and coronary flow reserve (CFR) were evaluated using echocardiography and microsphere-based coronary blood flow measurements.
- Histology and isolated coronary arteriole studies assessed cell engraftment and vessel reactivity.
Main Results:
- SVF cells successfully engrafted and persisted in the myocardium and coronary vasculature of aged rats post-injection.
- SVF treatment improved age-related diastolic dysfunction and increased stimulated coronary blood flow compared to controls.
- Isolated coronary arteriole reactivity remained largely unchanged, suggesting a systemic or paracrine effect.
Conclusions:
- Intravenous SVF cell injection effectively improves coronary microvascular function and diastolic function in an aging rodent model.
- SVF cells integrate into the aging heart's vasculature, offering a potential autologous cell therapy for age-related cardiac and microvascular dysfunction.
- This approach demonstrated safety, with no observed increase in arrhythmias or mortality in aged rats.
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