Dysplastic nevus syndrome: association with multiple primary neoplasms

Area of Science:

• Dermatology
• Oncology

Background:

• Dysplastic nevus syndrome is a condition characterized by numerous atypical moles.
• It is a known risk factor for developing malignant melanoma of the skin.

Observation:

• A 65-year-old man with dysplastic nevus syndrome presented with multiple neoplasms.
• These included extramammary Paget's disease of the scrotum, two cutaneous malignant melanomas, and two oral squamous cell carcinomas.
• Benign tumors such as lentigo maligna, dermatofibroma, and a cavernous hemangioma were also noted.

Findings:

• The patient's presentation expands on the known association between dysplastic nevus syndrome and cutaneous melanoma.
• It suggests a potential, less-established association with other non-cutaneous and non-melanoma malignancies.

Implications:

• This case underscores the importance of vigilant monitoring for various neoplasms in patients with dysplastic nevus syndrome.
• Further research may be warranted to explore the potential oncogenic pathways linking dysplastic nevus syndrome to a broader spectrum of cancers.