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Updated: Feb 6, 2026
09:20
Generation of Multicellular Human Primary Endometrial Organoids
Published on: October 4, 2019
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Direct Generation of Human Cortical Organoids from Primary Cells
Monique Schukking1,2, Helen C Miranda1,2, Cleber A Trujillo1,2
11 Department of Pediatrics, Rady Children's Hospital San Diego, University of California San Diego School of Medicine , La Jolla, California.
Stem Cells and Development
|August 26, 2018
Summary
This study presents a fast and affordable method for reprogramming somatic cells into cortical organoids. This approach enables large-scale sample generation for studying human neural development and cognition.
Area of Science:
- Neuroscience
- Developmental Biology
- Stem Cell Biology
Background:
- Studying human neurodevelopment and cognition is challenging due to limitations in current experimental models.
- Animal models offer incomplete recapitulation of human brain complexity, while human-induced pluripotent stem cells are costly and time-consuming to generate.
Purpose of the Study:
- To develop a rapid and cost-effective method for generating human cortical organoids.
- To enable large-scale sample generation for studying human neural development.
Main Methods:
- Somatic cell reprogramming.
- Direct generation of cortical organoids in a 96-well format.
Main Results:
- A proof-of-principle for a scalable and economical method for generating human neural models.
- Demonstrated the feasibility of generating a large cohort of samples for experimental assessment.
Conclusions:
- The described method significantly reduces the cost and time associated with generating human neural models.
- This approach facilitates large-scale studies of human neurodevelopmental variations and cognitive processes.
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