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Evaluation of the Storage Stability of Extracellular Vesicles
Published on: May 22, 2019
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Storage stability and solubilization ability of HPMC in curcumin amorphous solid dispersions formulated by Eudragit
Na Fan1, Pingping Ma1, Xin Wang1
1Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China.
Carbohydrate Polymers
|August 26, 2018
Summary
Hydroxypropyl methylcellulose E5 (HPMC) enhances curcumin amorphous solid dispersions (Cur ASDs) stability and solubility. The Eudragit E100/HPMC 6:1 formulation demonstrated superior solubilization, indicating its potential for improved drug delivery.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Curcumin amorphous solid dispersions (Cur ASDs) often face challenges with storage stability and poor solubility.
- Eudragit E100 (E100) is a polymer used in formulating amorphous solid dispersions.
- Hydroxypropyl methylcellulose E5 (HPMC) is a common pharmaceutical excipient.
Purpose of the Study:
- To investigate the role of HPMC as an auxiliary excipient in Cur ASDs formulated with E100.
- To evaluate the impact of HPMC on the storage stability and solubilization ability of Cur ASDs.
- To determine the optimal ratio of E100 to HPMC for enhanced curcumin solubility.
Main Methods:
- Formulation of Cur ASDs using Eudragit E100 and varying ratios of HPMC.
- Polarized light microscopy to assess physical stability and crystallization inhibition.
- In vitro dissolution experiments to evaluate drug release and solubility.
- Calculation of critical micelle concentration (CMC), molar solubilization ratio (MSR), and micelle-water partition coefficient (Kmc) to quantify solubilization capacity.
Main Results:
- HPMC effectively inhibited crystallization of Cur ASDs, thereby enhancing storage stability.
- HPMC, acting as a non-ionic surfactant, improved the solubilization ability of curcumin in acidic conditions.
- The Eudragit E100/HPMC 6:1 formulation exhibited the highest solubilization ability.
- The solubilization mechanism of the E100/HPMC 6:1 formulation differed from that of HPMC alone or the E100/HPMC 1:1 ratio.
Conclusions:
- HPMC is a valuable auxiliary excipient for improving the stability and solubility of curcumin amorphous solid dispersions.
- The Eudragit E100/HPMC 6:1 ratio provides superior solubilization of curcumin, suggesting its potential for enhanced oral bioavailability.
- Understanding the role of HPMC in micelle formation and solubilization is crucial for optimizing amorphous solid dispersion formulations.
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